Child Life and Health

Dr Jay Shetty

Jay Shetty's research focuses on the long term outcome in childhood epilepsy, neuro-inflammation and CNS infections. Clinical trials in paediatric epilepsy, CNS infection and inflammation.

Dr Jay Shetty

Consultant Paediatric Neurologist, NRS Fellow, Honorary Senior Lecturer and CLaH Module Organiser

  • Child Life and Health

Contact details

Biography

  • MB BS- University of Mysore, India
  • Research Fellow for WHO and ICMR- All India Institute of Medical Sciences, New Delhi
  • Paediatric Training in Dundee and Leeds
  • Paediatric Neurology Training Edinburgh and Dundee

Group Members

  • Dr Gemma Buxton, Research Fellow in Child Life and Health

  • Mrs Jacqueline McPherson, Neurology Nurse Specialist, Department of Paediatric Neurosciences Edinburgh

  • Dr Elizabeth Pilley, Paediatric Neurology Grid Trainee, Edinburgh.
  • Libby Chatterton Dickson, Medical student, Edinburgh University
  • Ailidh Ramsay, Medical student, St Andrews University

Research Background

Childhood epilepsies are one of the commonest chronic neurological disorders and in Scotland there are 5000-7000 young people who are estimated to have active epilepsy. When a child is diagnosed with epilepsy the main focus is on seizure management. Apart from the seizure management there are significant other factors in childhood epilepsies like learning and behavioural problems, increased incidence of psychiatric co-morbidities, risks of injuries and side effects of antiepileptic drugs, impact on quality of life, impact on future employment and risks of mortality.

My aim is to study the long term outcome of child epilepsy through routinely collected clinical data linked with imaging data, genetic data, maternity data and education data in these children.

My other area of interest is CNS infection and inflammation. I have a particular interest in enterovirus infection and outcome. Neuro-inflammatory conditions (MS, ADEM, NMO etc) are rare in children and I am keen to explore newer treatment modalities in these conditions and study long term follow up.

Research Overview

Currently I am involved in the following studies:

Edinburgh Paediatric Epilepsy Cohort study

Childhood epilepsy epidemiology and outcome study using routinely collected clinical data and linking with other datasets. There are a number of professionals involved in childhood epilepsy assessment, investigation, management, information provision, and managing comorbidities. The data collected routinely by different professionals are in different databases. Linking these data will be invaluable in understanding the aetiology, diagnosis and classification, planning appropriate treatment, providing accurate information, managing comorbidities and predicting long term outcome. In Scotland we have great opportunity of data linkage through Community Health Index (CHI) number, a unique individual identifier. We would like to link the epilepsy clinical datasets to other databases to explore following aspects of childhood onset epilepsy

Enterovirus CNS infection

I am involved in looking at the enterovirus CNS infection spectrum and in particular interested in EV D68 associated Acute Flaccid Paralysis. I am currently part of European Collaboration to study EV D68 infections.

Treatment of Neuro-inflammatory disorders

Clinical trials for the treatment of Paediatric MS, Encephalitis and other rare conditions. There are limited treatment options in children with these rare conditions and I am actively participating in clinical trials with newer treatment options.

Sources of Funding

  • 2015-2022: Novartis. A double-blind, randomized, multicentre, active controlled study to evaluate the safety and efficacy of fingolimod administered orally once daily versus interferon β-1a i.m. once weekly in pediatric patients with multiple sclerosis. Role: Principle Investigator.
  • 2017-2019: Action Medical Research & RS Macdonald Charitable Trust. Investigation of sleep quality and prevalence of sleep-disordered breathing in children and young people with epilepsy. Role: Co-Investigator.
  • 2016-2019: NIHR. A phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the management of children with encephalitis (The IgNiTE study). Role: Principle Investigator.
  • 2017-2019: NIHR. A pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II). Role: Co-Investigator.
  • 2014-2018: Epilepsy Research UK. The Genetic and Autoimmune Causes of Childhood Epilepsy (GACE) study. Role: Co-Investigator.

Publications

Bashir S, Chatterton Dickson L, Davies M, Easter J, Gisbey G, Yu T, Leonard P, Shetty J. Head Injury and A&E attendance in Children-Scottish Population Cohort

Shetty J, Greene SA, Mesalles-Naranjo O, Kirkpatrick M. Adherence to antiepileptic drugs in children with epilepsy in a Scottish population cohort. Dev Med Child Neurol. 2016 May;58(5):469-74

Shetty J. Neonatal seizures in hypoxic-ischaemic encephalopathy--risks and benefits of anticonvulsant therapy. Dev Med Child Neurol. 2015 Apr;57 Suppl 3:40-3.

Mayer J, Briton Z, Brooks R, Donald A, Forrest K, Hemmingway C , Kumar R, Mewasingh L , Mordekar S,  Ong M, Portela M, Prabhakar P, Robinson R, Shetty J, Singh J, Smallbone T, Wassmer E , West S , Zuberi, Lim M, Kneen R. National survey of intravenous immunoglobulin use in paediatric neurology. Dev Med Child Neurol. 2016 Jan;58 Suppl 1:77-80.

Pilley E, Browning J, Eunson P, McWilliam K, Tallur K, Chin R, McLellan A, Templeton K, Shetty J. Case series of acute flaccid paralysis attributable to Enterovirus D68 - the beginning of a new epidemic? Dev Med Child Neurol. 2017 Jan; 59;

Shetty J, Eunson P, McWilliam K, Tallur K, Chin R, McLellan A Infantile Spasms- Nitrazepam as first line treatment? Epilepsia, 55(Suppl. 2):247–274, 2014

Shetty J, Fraser J, Goudie D, Kirkpatrick M. Aicardi Syndrome in a 47XXY male- a variable phenotype? Eur J Paediatr Neurol. 2014 Jul;18(4):529-31

de Vries B, Stam AH, Kirkpatrick M, Vanmolkot KR, Koenderink JB, van den Heuvel JJ, Stunnenberg B, Goudie D, Shetty J, Jain V, van Vark J, Terwindt M,Frants RR, Haan J, van den Maagdenberg AM, Ferrari MD. Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel   de novo ATP1A2 mutation. Epilepsia. 2009 Nov;50(11):2503-4

Shetty J, Kirkpatrick M, Jollands A,; Respinger C,  Cunningham J, Medley B,Hislop G, Goudie D, Berg J, Lambert J, Belleli D. GABRA3 (GABAA receptor α3) gene duplication –a potential cause of a severe X-linked early onset movement disorder and associated epileptic encephalopathy disorder and associated epileptic encephalopathy. Epilepsy Currents. December 2011, 12 (S1), Pg 277.

Shetty J, Greene S, McGilchrist M, Kirkpatrick M. Trends in primary care drug prescribing in children and adolescents: changing epidemiology or evolving practice? 1University of Dundee, Dundee, UK; 2NHS Tayside, Dundee, UK. Arch Dis Child. 2007 April; 92(Suppl1): A68–A70.

Honours and Awards

  • Indian Council of Medical Research Student Fellowship
  • Next Generation Clinical Academic Role Model award by BMA

Public Engagement Activities

  • Epilepsy Education through Scottish Paediatric Epilepsy Network

Other Responsibilities

  • Undergraduate Module Lead - Child Life and Health, University of Edinburgh
  • Consultant Paediatric Neurologist
  • Scottish Paediatric Epilepsy Surgery Team
  • Co-Chair, SIGN Guideline for Paediatric Epilepsy
  • Honorary Senior Lecturer, University of Edinburgh
  • NHS Research Scotland Research Fellow

Collaborators