Caroline Hayward (Affiliate)
Quantitative Traits in Health and Disease
Section: Biomedical Genomics
Research in a Nutshell
My core research interest is in the study of the genetics of quantitative traits (QTs) and their relationship to health and disease. I study the genetics of populations from Croatia and Scotland, in which a wide range of data was collected from medical examinations, questionnaires and biochemical assays. Plasma, serum and urine have been stored from each cohort participant, allowing additional lab-based measures to be derived, and new hypotheses to be tested. Recent advances in Electronic Health Record linkage has increased the availability of clinical measures and enables the longitudinal follow-up of participants which can then be associated with genetic factors.
I have a major interest in kidney-related traits and lead a European Consortium of Urinary Traits as well as being a participating member of the Chronic Kidney Disease Genetic consortium (CKDGen).
The diversity of phenotypes measured in these cohorts has enabled my research to cover quantitative traits relevant to a very broad spectrum of medically relevant conditions including lung function, pain, heart disease and the consequences of germline viral integration.
|Caroline Hayward||Group Leader|
|Shona Kerr||Project Manager|
|Susan Campbell||Technical Support|
|Anne Richmond||Data Analyst|
|Christina Joseph||PhD student|
- Institute of Genetics and Cancer, University of Edinburgh: Professor Malcolm Dunlop, Dr Toby Hurd, Professor Andrew Jackson, Professor David Porteous, Professor Colin Semple, Professor Martin Taylor, Dr Pippa Thomson, Professor Wendy Bickmore.
- University of Edinburgh, Edinburgh, UK: Professor Harry Campbell, Professor Ian Deary, Professor Andrew McIntosh, Professor Igor Rudan, Professor Brian Walker, Professor Sarah Wild
- University of Glasgow, Glasgow, UK Professor Sandosh Padmanabhan and Professor Christian Delles (Institute of Cardiovascular and Medical Sciences); Professor Ruth Jarrett (Institute of Infection, Immunity and Inflammation)
- University of Dundee, Dundee, UK Professor Colin Palmer, Professor Blair Smith (School of Medicine).
- University of Aberdeen, Aberdeen UK Dr Lynne Hocking (Institute of Medical Sciences)
- University of Split, Croatia, Dr Ozren Polasek and Dr Ivana Kolcic (Public Health Sciences)
- University of Zagreb, Croatia Professor Gordan Lauc (Faculty of Pharmacy and Biochemistry)
- Institute for Anthropological Research, Zagreb, Croatia, Dr Branca Janicijevic, Dr Nina Smolej-Narancic
- University of Zurich, Switzerland, Professor Olivier Devuyst
- University of Leicester, Leicester, UK, Professor Martin Tobin (Department of Health Sciences)
- University of Lausanne, Switzerland, Professor Murielle Bochud (CHUV) Dr Zoltan Kutalik (Swiss Institute of Bioinformatics)
Partners and Funders
- CROATIA Cohorts
- Generation Scotland
- VIKING Health Study
human genetics, quantitative traits, isolate populations, kidney function, disease mechanisms, phenotyping, linkage, 'omics,
GWAS, Quantitative genetics, Genomics, genotype analysis, electronic health record linkage