Bryan Conway Research Group
Information on the research interests, projects, and members of Bryan Conway's Research Group.
Dr Bryan Conway
Senior Clinical Lecturer
Diabetic kidney disease is the single most common cause of end-stage renal disease in the Western world, accounting for 20% of all incident cases of dialysis in the UK and up to 50% in the US. I am investigating the pathogenesis of diabetic nephropathy, combining novel rodent models with unbiased gene expression analysis. Good blood sugar and blood pressure control can result in regression of nephropathy in patients with diabetes and I am particularly interested in dissecting the mechanisms by which this may occur. This work is in collaboration with Prof John Mullins, Dr Matt Bailey and Dr Laura Denby from the Centre for Cardiovascular Science and Dr Jeremy Hughes and Prof Neil Henderson from the CIR. I am also collaborating with the Edinburgh Type 2 Diabetes Study Investigators to examine the utility of urinary biomarkers to predict renal outcome in patients with type 2 diabetes. The recent increase in the incidence of diabetic nephropathy is largely driven by the epidemic of obesity and type 2 diabetes. Therefore I am collaborating with Prof Nik Morton from the Centre for Cardiovascular Science to investigate the pathogenesis of obesity and type 2 diabetes.