Alexander von Kriegsheim
Network Biology and Proteomics
Research in a Nutshell
My research group aims to identify potential weaknesses in the otherwise robust signalling networks of cancer cells which can be exploited for therapeutic intervention. We specifically focus on the initiating events in cancer establishment as well as the events triggering the spread of cancer throughout the body.
We commonly use mass spectrometry methods, such as interaction, expression, exosome/secretion and PTM proteomics to initially generate signalling networks. Subsequently we use this integrated information to generate new and testable hypotheses. This unbiased data which we use in combination with mathematical modelling can explain unintuitive cellular behaviours. Currently, we are focusing on how hydoxylations can regulate tumour initiation and how the modification by ISG15, a small ubiquitin-like protein modifier, promotes tumour cell invasion and metastasis.
In addition, we collaborate with groups worldwide and across all disciplines which require accurate and quantitative mass spectrometry data sets to further their research.
People |
|
| Alexander von Kriegsheim |
Principal Investigator, HTPU and Mass Spectrometry Facility Manager |
| Roopesh Krishnankutty | Lab Manager |
| Jair Marques Junior | Senior Mass Spec Research Officer |
Contact
Collaborations
- Cormac Taylor (UCD Dublin)
- Boris Kholodenko (Systems Biology Ireland)
Partners and Funders
- Breast Cancer NOW/project/2014-2018/190,000
- Wellcome Trust/ISSF2/2016/70,000
- Carnegie Trust
Scientific Themes
Hypoxia signalling, ISG15 regulated networks, cell migration and invasion
Technology Expertise
Mass spectrometry, systems biology, signalling network biology