Clinical Translational Research in Breast Cancer
Research in a Nutshell
Dr Oikonomidou’s major ongoing interests include clinical and translational research in breast cancer. They include:
- The NEO study: a study of factors predicting response to neo-adjuvant chemotherapy in breast cancer patients. CRUK Grant-Development Fund.
- Bioinformatics analysis of the NEO pilot study. MRC Confidence in Concept Scheme.
- The role of Magnetic Resonance Phosphorous Spectroscopy (31P-MRS) in detecting changes in heart function associated with the use of chemotherapy drugs used to treat breast cancer. University of Edinburgh Internal fund.
- Novel sample preparation for improved circulating tumour DNA analysis. Chief Scientist Office Research Grant.
- Clinical usefulness of assessing VEGFR-2 levels pre and post surgery in women with breast cancer.
- A study of the effect of surgery on circulating tumour DNA and correlation with disease recurrence.
- DNA Methylation Profiling of cfDNA in breast cancer.
|Olga Oikonomidou||Principal Investigator, Consultant Medical Oncologist and Clinician Scientist in Breast Oncology|
|Richard Bownes||PhD student (co-supervised with Andy Sims)|
- Dr Andy Sims, Senior Research Fellow and Group Leader, Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research Centre
- Professor Tim Aitman, Professor of Molecular Pathology and Genetics, Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh
- Dr Martin Denvir, Reader and Cardiologist, Centre of Cardiovascular Science, University of Edinburgh
- Dr Nicholas R. Leslie, Associate Professor, Institute of Biological Chemistry, Biophysics and Bioengineering, Nasmyth Building, Heriot-Watt University
Partners and Funders
- Chief Scientist Office Research Grant (£220,883) Co-PI – Novel sample preparation for improved circulating tumour DNA analysis. July 2015-
- MRC Confidence in Concept Scheme - Translation of Medical Informatics (£60,000) Co-PI –Bioinformatics analysis of the NEO pilot study. May 2014-September 2015
- CRUK Grant-Development Fund (£25,000) PI – for ‘’The NEO study: a study of factors predicting response to neoadjuvant chemotherapy in breast cancer patients’’. April 2014-May 2016
- University of Edinburgh Internal fund (£40,000) Co-PI – the role of Magnetic Resonance Phosphorous Spectroscopy (31P-MRS) in detecting changes in heart function associated with the use of chemotherapy drugs used to treat breast cancer. December 2014-December 2015
Breast cancer, Translational studies, Genomics, Transcriptomics, cfDNA, DNA methylation, Personalised Medicine.
Trascriptomics, ddPCR, Sanger Sequencing.