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Cancer Research UK Edinburgh Centre: MRC Institute of Genetics & Molecular Medicine

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Olga Oikonomidou

Clinical Translational Research in Breast Cancer

Research in a Nutshell

Olga Oikonomidou
Dr Olga Oikonomidou - Consultant Medical Oncologist and Clinician Scientist in Breast Oncology

Dr Oikonomidou’s major ongoing interests include clinical and translational research in breast cancer. They include:

  • The NEO study: a study of factors predicting response to neo-adjuvant chemotherapy in breast cancer patients. CRUK Grant-Development Fund.
  • Bioinformatics analysis of the NEO pilot study. MRC Confidence in Concept Scheme.
  • The role of Magnetic Resonance Phosphorous Spectroscopy (31P-MRS) in detecting changes in heart function associated with the use of chemotherapy drugs used to treat breast cancer. University of Edinburgh Internal fund.
  • Novel sample preparation for improved circulating tumour DNA analysis. Chief Scientist Office Research Grant.
  • Clinical usefulness of assessing VEGFR-2 levels pre and post surgery in women with breast cancer.
  • A study of the effect of surgery on circulating tumour DNA and correlation with disease recurrence.
  • DNA Methylation Profiling of cfDNA in breast cancer.

 

Research Programme

 

People

  
Olga Oikonomidou Principal Investigator, Consultant Medical Oncologist and Clinician Scientist in Breast Oncology

Clare Bartos

 Tissue Consenter/Processor 
Richard Bownes PhD student (co-supervised with Andy Sims)

Contact

Olga.Oikonomidou@ed.ac.uk

Collaborations

  • Dr Andy Sims, Senior Research Fellow and Group Leader, Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research Centre
  • Professor Tim Aitman, Professor of Molecular Pathology and Genetics, Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh
  • Dr Martin Denvir, Reader and Cardiologist, Centre of Cardiovascular Science, University of Edinburgh
  • Dr Nicholas R. Leslie, Associate Professor, Institute of Biological Chemistry, Biophysics and Bioengineering, Nasmyth Building, Heriot-Watt University

Partners and Funders

  • Chief Scientist Office Research Grant (£220,883) Co-PI – Novel sample preparation for improved circulating tumour DNA analysis. July 2015-
  • MRC Confidence in Concept Scheme - Translation of Medical Informatics (£60,000) Co-PI –Bioinformatics analysis of the NEO pilot study. May 2014-September 2015
  • CRUK Grant-Development Fund (£25,000) PI – for ‘’The NEO study: a study of factors predicting response to neoadjuvant chemotherapy in breast cancer patients’’. April 2014-May 2016
  • University of Edinburgh Internal fund (£40,000) Co-PI – the role of Magnetic Resonance Phosphorous Spectroscopy (31P-MRS) in detecting changes in heart function associated with the use of chemotherapy drugs used to treat breast cancer. December 2014-December 2015

Scientific Themes

Breast cancer, Translational studies, Genomics, Transcriptomics, cfDNA, DNA methylation, Personalised Medicine.

Technology Expertise

Trascriptomics, ddPCR, Sanger Sequencing.

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