Mr. O’Neill graduated from Edinburgh Medical School with Honours in 2005 and joined the South-East Scotland surgical training programme in 2007. He was appointed to the ECAT training programme in 2009 and completed his PhD in the CRUK Edinburgh Centre in 2013 under the supervision of Professor Ted Hupp and Professor Rebecca Fitzgerald.
His current research focus is on oesophageal cancer, the fourth leading cause of cancer death in Scotland.
Oesophageal adenocarcinoma (OAC), the predominant subtype, is largely resistant to current chemotherapies and the majority of patients succumb to systemic disease. Mr. O’Neill's research aims to identify novel therapeutic targets for this disease. He has established an oesophageal tissue resource and is using proteomic methods to identify cancer-specific proteins and computational and network analysis methods to understand OAC biology. He leads the Edinburgh component of the OCCAMS multicentre collaboration; currently undertaking the oesophageal adenocarcinoma genome project.
Mr. O’Neill has both wet-lab, computational and clinical research studies in progress and welcomes motivated students to get in touch by email if interested in joining this work.