Cancer Research UK Edinburgh Centre

Charlie Gourley

Nicola Murray Centre for Ovarian Cancer Research

C.Gourley
Professor Charlie Gourley - Chair of Medical Oncology and Honorary Consultant in Medical Oncology. Director, Nicola Murray Centre for Ovarian Cancer Research

Research in a Nutshell 

Ovarian cancer is the fourth most common cause of female cancer death in the UK. Until recently it has been treated as a single disease entity. There is now considerable evidence to demonstrate that ovarian cancers differ in their tissues of origin, their genetic abnormalities, their responsiveness to chemotherapy and the ultimate outcome for patients. 

It is our aim to investigate the biology of this disease at the interface between the laboratory and the clinic in order to generate findings that can be directly translated into patient benefit. We do this by characterising the molecular changes that occur in different ovarian cancers and determining how this affects their responsiveness to chemotherapy or novel biological agents. In some instances this has led to the description of novel molecular subtypes.

 

Research Programme

Nicola Murray Foundation

Nicola Murray Foundation
c.gourley-group-3.2018

People

 
Charlie Gourley

Principal Investigator, Professor of Medical Oncology and Director of the Nicola Murray Centre for Ovarian Cancer Research

Laura Agundez Muriel Research Assistant
Mike Churchman Lab Manager
Carol Dawson IT Developer
Miriam Kathleen Gomez PhD Student
Pamela Haig Research Consenter / Processor
Simon Herrington Professor of Molecular Cancer Pathology
Robb Hollis PhD Student
Jessica Lim ECAT Clinical Research Fellow
David Melton Chair in Somatic Cell Genetics
Tzyvia Rye Data Manager
John Thomson Research Fellow

Thomas Parry 

PhD Student
Barbara Stanley  Clinician Scientist
Yasushi IIDA  Visiting Research Fellow

Contact

Charlie.Gourley@igmm.ed.ac.uk

PA: Laura.Commins@igmm.ed.ac.uk

Collaborations

  • Beatson Institute, Glasgow, UK (Edinburgh and Glasgow Ovarian Cancer Group): Dr Patricia Roxburgh, Dr Ros Glasspool, Dr Seth Coffelt, Dr David Millan and Dr Gareth Bryson.
  • Queens University Belfast, Belfast, UK: Professor Richard Kennedy and Dr Nuala McCabe.
  • Peter Mac Institute, Melbourne, Australia: Professor Ian Campbell and Dr Kylie Gorringe.
  • University of Sydney, Sydney, Australia: Professor Anna de Fazio.
  • National University of Singapore, Singapore: Dr Ruby Huang and Dr David Tan.
  • Netherlands Cancer Institute, Amsterdam, Netherlands: Dr Christianne Lok.
  • Sunnybrook Research Institute/University of Toronto, Toronto, Canada: Prof Helen Mackay.
  • Jikei University School of Medicine, Tokyo, Japan: Professor Aikou Okamoto.

Partners and Funders

  • Nicola Murray foundation/Charitable donation
  • AstraZeneca/Scottish Chief Scientist Office/Scottish Genome Partnership: Research grant.
  • Stratified Medicine Scotland-Innovation Centre: Research grant.
  • Cancer Research UK: Core funding, research grants and PhD fellowships.
  • Medical Research Council: Molecular Pathology Node and PhD fellowships.
  • University of Sciences and Technology, Pakistan.
  • Jikei University School of Medicine, Tokyo, Japan.

Scientific Themes

Ovarian cancer genomics and transcriptomics, translational research