Tissue and Cellular Homeostasis
We are interested in how E3 Ubiquitin-Protein Ligases maintain tissue, cellular and protein homeostasis and how their deregulation contributes to human disease. Our current work focuses on the role of the N-end Rule E3 UBR5 and its role in cancer and rheumatological disease, with a strong focus on understanding the effects on cell differentiation, proliferation and death as well as the underlying molecular mechanisms. We use a wide variety of cell, organ and animal models in combination with a comprehensive array of molecular techniques.
Principal Investigator, Tenure Track Fellow and UoE Chancellor’s Fellow
|Malgorzata Kubiak||MRes student|
Ubiquitin signalling; E3; Osteoarthritis; Chondrocyte biology; UBR5; EDD1; Hedgehog Signalling; Programmed Cell Death, IAP proteins, Caspases
Drosophila genetics; Mouse genetics; Ubiquitin signalling; Hedgehog signalling; uCT, Histology