Cancer Research UK Edinburgh Centre

Mark Ditzel

Tissue and Cellular Homeostasis

M.Ditzel group
Dr Mark Ditzel - Tenure Track Fellow

Research in a Nutshell 

We are interested in how E3 Ubiquitin-Protein Ligases maintain tissue, cellular and protein homeostasis and how their deregulation contributes to human disease. Our current work focuses on the role of the N-end Rule E3 UBR5 and its role in cancer and rheumatological disease, with a strong focus on understanding the effects on cell differentiation, proliferation and death as well as the underlying molecular mechanisms. We use a wide variety of cell, organ and animal models in combination with a comprehensive array of molecular techniques.


Research Programme


M.Ditzel group


Mark Ditzel 

Principal Investigator, Tenure Track Fellow and UoE Chancellor’s Fellow

David Mellis Post-Doc
Malgorzata Kubiak MRes student



  • Professor Robert Hill, MRC Human Genetics Unit, University of Edinburgh, UK
  • Professor Mike Warman, Harvard University, USA
  • Professor Stuart Ralston, IGMM, University of Edinburgh, UK
  • Professor Owen Sansom, Beatson Cancer Institute, UK
  • Professor Donald Salter, IGMM, University of Edinburgh, UK
  • Dr Owen Davis, Cardiff, UK
  • Dr Fabio Nudelmann, Edinburgh, UK

Partners and Funders

  • University of Edinburgh / Chancellors Fellowship / 5 years / £75K
  • Carnegie Trust / Research Incentive Grant / 8 months / £7.5K

Scientific Themes

Ubiquitin signalling; E3; Osteoarthritis; Chondrocyte biology; UBR5; EDD1; Hedgehog Signalling; Programmed Cell Death, IAP proteins, Caspases

Technology Expertise

Drosophila genetics; Mouse genetics; Ubiquitin signalling; Hedgehog signalling; uCT, Histology