Biomedical Sciences

Progress in tissue engineered bone production: new publication from the Paxton Lab

Paxton Lab PhD researcher, Vinothini Prabhakaran, and colleagues have published a new study focussed on the production of tissue-engineered bone macro-tissues.

A novel process for engineering 3D bone macro-tissues using a guided fusion approach

The study, published in the journal Frontiers in Endocrinology, describes a novel process for engineering 3D bone macro-tissues using a guided fusion approach.

This methodology uses a combination of 3D printing, spheroid formation and 3D cell culture to generate bone-like constructs in the laboratory. It is hoped that these macro-tissues could be used for implantation after bone injury or disease or as a screening tool for bone pharmaceutical agents in the future.

This novel approach is also being trialled for other tissue types as part of Vinothini’s PhD research.

Read the full publication which was part of a Special Issue on Women in Bone Research here:

Engineering three-dimensional bone macro-tissues by guided fusion of cell spheroids - PubMed (nih.gov)