Probiotic hope for Parkinson's disease
Dr Maria Doitsidou's lab (Centre for Discovery Brain Sciences) and colleagues from Dundee University have identified a probiotic – or so-called good bacteria – which prevents the build-up of a protein which is linked with Parkinson’s. These findings have been published in Cell Reports.
In people with Parkinson’s, alpha-synuclein protein builds up and forms toxic clumps which are associated with the death of dopamine producing nerve cells. The loss of dopamine is what causes motor symptoms in Parkinson’s.
Using roundworms, scientists found that a probiotic called Bacillus subtilis could not only protect against the build-up of this protein, but can also clear some of the already formed protein clumps.
These new findings could pave the way for future studies that gauge how supplements such as probiotics impact Parkinson’s.
Summary
The results provide an opportunity to investigate how changing the bacteria that make up our gut microbiome affects Parkinson’s. The next steps are to confirm these results in mice, followed by fast-tracked clinical trials since the probiotic we tested is already commercially available.
Further Information
Media coverage
What’s the gut got to do with Parkinson’s? Ask the expert (Parkinson's UK blog/magazine)
Gut bacteria could guard against Parkinson’s (Parkinson's UK)
Could a common probiotic bacteria prevent Parkinson's disease? (Herald Scotland)
Probiotic could guard against Parkinson's ( Neurosience News)
Gut bacteria could improve symptoms in Parkinson’s sufferers, study suggests (Evening Express)