Biomedical Sciences

New study identifies activity-dependent bulk endocytosis proteome

A new study led by Professor Mike Cousin (Centre for Discovery Brain Sciences and Muir Maxwell Epilepsy Centre) published in PNAS has revealed the ADBE proteome, which will allow for researchers to decode how ABDE controls brain function.  

The maintenance of neurotransmission by synaptic vesicle recycling is critical to brain function. During intense brain activity the dominant synaptic vesicle recycling mode is activity-dependent bulk endocytosis (ADBE), suggesting that ADBE has a key role in neurotransmission, although the exact role has yet to be determined.   

This work provides the molecular inventory of ADBE, a resource that will be of significant value to researchers wishing to modulate neurotransmission during intense neuronal activity in both health and disease, and could have implications for future epilepsy treatments.

The [ADBE proteome] is the equivalent of the Rosetta Stone for understanding how this pathway controls brain function. It should provide a rich resource of new avenues to explore for new epilepsy treatments, which are urgently needed, since around one third of children with epilepsy cannot control their seizures with the treatments that are currently available.

Prof Mike CousinCentre for Discovery Brain Sciences and Muir Maxwell Centre

Further information

Original paper in PNAS

Prof Mike Cousins lab profile