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New Tools for Measuring Synapses

Researchers from Anatomy@Edinburgh have developed an updated version of their NMJ-morph software platform for analyzing synaptic morphology.

The automated macro – ‘aNMJ-morph’ – is freely available at Edinburgh DataShare and the supporting article has just been published in Royal Society Open Science. 

NMJ-morph allows different research groups to measure synapses and share data easily, whilst the new aNMJ-morph macro significantly increases the speed of data collection. These approaches have now been used in several major studies of the human neuromuscular junction (NMJ) in both health (Cell Reports) and disease (Journal of Clinical Investigation).

aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology
Image: Minty G et al. 2020. aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology. Royal Society Open Science. 7: 200128.

Related links

Edinburgh DataShare 'aNMJ-morph' macro

Royal Society Open Science - aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology

Open Biology - NMJ-morph reveals principal components of synaptic morphology influencing structure–function relationships at the neuromuscular junction

Cell Reports - Cellular and Molecular Anatomy of the Human Neuromuscular Junction

Journal of Clinical Investigation - Neuromuscular junctions are stable in patients with cancer cachexia