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New paper describing the formation of a 3-D co-cultures for interface studies

Researchers from Anatomy@Edinburgh have published a new paper in Regenerative Biomaterials.

Images shows tendon cells (green) and bone cells (red) cultured in one of the new systems developed as part of the study
Images shows tendon cells (green) and bone cells (red) cultured in one of the new systems developed as part of the study. (A) Agarose, (B) gellan and (C) fibrin are showing an acceptably perpendicular interface and (D) collagen showed an angled interface (scale bar = 200 µm).

This work focusses on investigating the methods and materials needed to ensure that co-cultures of cells to mimic areas of the body where two tissue types join together (e.g. the bone-tendon interface or enthesis) are made successfully.

The Paxton Lab is now using these methodologies to study what happens at tissue interfaces in the musculoskeletal system as an in vitro model to inform repair and regeneration strategies for damaged tissues.

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The paper is free to download from Regenerative Biomaterials.