SynthSys

Extraordinary People: Dr Tilo Kunath

Dr Tilo Kunath, SynthSys member and Reader in Regenerative Neurobiology in the School of Biological Sciences is the latest innovator to be spotlighted in Edinburgh Innovations Extraordinary People campaign.

Tilo is making crucial advancements in the fight against Parkinson’s disease.

Recent work funded by the UK Centre for Mammalian Synthetic BiologyUCB and Cure Parkinson’s.  has the potential to significantly affect the development of next-generation cell-based therapies.

The CRISPR- Cas9  gene editing tool allows Tilo Kunath and team  to edit parts of the genome by removing, adding or altering specific sections of the DNA sequence. These new laboratory-generated midbrain dopaminergic (mDA) cells did not develop signs of the disease, Lewy bodies, unlike those that were not gene-edited.  

Transplantation of dopamine-producing neurons has proved useful in disease management because it can reinnervate Parkinson’s affected brain regions, restore dopamine levels and provide symptom relief. These advances could be most beneficial in young-onset Parkinson’s and younger patients.

Read about Tilo's journey

 

Dr Tilo Kunath
Dr Tilo Kunath

Related Links

Edinburgh Innovations Extraordinary People

Dr Tilo Kunath

UK Centre for Mammalian Synthetic Biology