Stem cell biology
We conduct fundamental research into the biology and engineering of mammalian stem cells. Our aim is to provide the understanding of stem cells required to develop new therapies to treat human disease and injury.
Our research programme covers three main areas:
- self-renewal and differentiation of stem cells
- developmental origin of stem cells
- stem cell derivation
The major focus is to define the molecular mechanisms that act to maintain the stem cell state or to promote its change into specific cell-types. Increased understanding of these mechanisms will pave the way for the use of in vitro-generated or expanded stem cells and their differentiated derivatives for assessing potential new drugs and, in the longer term, treatment of disease by cell therapy.
Our stem cell research is carried out collaboratively with medical colleagues through the MRC Centre for Regenerative Medicine.