Prof Paul Sharp
Location: Ashworth G61C
Telephone: 651 3684
Website: No details available
Group members: No details available
|1982||Ph.D., Department of Genetics, University of Edinburgh|
|1982-1992||Lecturer in Genetics, Trinity College, University of Dublin|
|1985-1987||Visiting Assistant Professor, University of Texas at Houston|
|1992-1993||Associate Professor of Genetics, Trinity College, University of Dublin|
|1992||Elected to membership, European Molecular Biology Organization|
|1993-2007||Professor of Genetics, University of Nottingham|
|1993||Elected to membership, Royal Irish Academy|
|2008||President, Society for Molecular Biology and Evolution|
|2007-Present||Professor of Genetics, University of Edinburgh|
Molecular evolution and genomics, Infectious disease and immunology
MSc in Quantitative Genetics and Genome Analysis
Evolution of viruses, and evolution of bacteria. My research employs computer analyses of nucleotide and protein sequence data to address a range of evolutionary questions.
Viral evolution: what are the origins of human viruses, and what factors influence their genetic diversity? A particular focus has been the origins and evolution of AIDS viruses.
Bacterial evolution: what do bacterial genome sequences tell us about evolution? Two particular areas involve the evolution of synonymous codon usage bias, and the evolution of repetitive sequence families.
Keele, B.F., Van Heuverswyn, F., Li, Y., Bailes, E., Takehisa, J.,Santiago, M., Bibollet-Ruche, F., Chen, Y., Wain, L.V., Liegeois, F., Loul, S., Ngole, E.M., Bienvenue, Y., Delaporte, E., Brookfield , J.F.Y., Sharp, P.M., Shaw, G.M., Peeters M. & Hahn, B.H. (2006) Chimpanzee reservoirs of pandemic and non-pandemic HIV-1. Science 313:523-526.
Wilson, L.A. & Sharp, P.M. (2006) Enterobacterial Repetitive Intergenic Consensus (ERIC) sequences in Escherichia coli: evolution and implications for ERIC-PCR. Molecular Biology and Evolution 23:1156-1168.
Sharp, P.M., Bailes, E., Grocock, R.J., Peden, J.F. & Sockett, R.E. (2005) Variation in the strength of selected codon usage bias among bacteria. Nucleic Acids Research 33:1141-1153.
Sharp, P.M., Shaw, G.M. & Hahn, B.H. (2005) Simian immunodeficiency virus infection of chimpanzees.Journal of Virology 79:3891-3902.
Bailes, E., Gao, F., Bibollet-Ruche, F., Courgnaud, V., Peeters, M., Marx, P.A., Hahn, B.H. & Sharp, P.M. (2003) Hybrid origin of SIV in chimpanzees. Science 300:1713.
Sharp, P.M. (2002) Origins of human virus diversity. Cell 108:305-312.