Professor Brian Charlesworth
Location: Ashworth 2 115
Telephone: +44 (0) 131 650 5751
Website: No details available
Group members: No details available
|1966||BA in Natural Sciences (1st Class Honours), University of Cambridge|
|1969||PhD in Genetics, University of Cambridge|
|1969 - 1971||Post-doctoral Fellow, University of Chicago|
|1971 - 1974||Lecturer in Genetics, University of Liverpool|
|1974 - 1982||Lecturer in Biology, University of Sussex|
|1982 - 1984||Reader in Biology, University of Sussex|
|1985 - 1992||Professor of Ecology and Evolution, University of Chicago|
|1992 - 1997||G.W. Beadle Distinguished Service Professor of Ecology and Evolution, University of Chicago|
|1997 - 2007||Royal Society Research Professor, Institute of Evolutionary Biology, University of Edinburgh|
|2007 - 2010||Professor and Head of Institute of Evolutionary Biology, University of Edinburgh|
|1991||Fellow of the Royal Society|
|1996||Honorary Fellow of the American Academy of Arts and Sciences|
|1999||President, Society for the Study of Evolution|
|2000||Fellow of the Royal Society of Edinburgh; Darwin Medal of the Royal Society|
|2006||President, Genetics Society (UK), until 2009|
|2006||Sewall Wright Award, American Society of Naturalists|
|2007||Frink Award, Zoological Society of London|
Molecular Evolution and Genomics
Genomes and Genomics (3rd year): 3 lectures Evolutionary Biology Honours Elective: The Evolution of Sex and Breeding Systems (4 lectures and 2 discussions) Genetics Honours Elective: Topics in Evolutionary Genomics (4 lectures and 2 discussions) MSc in Quantitative Genetics and Genome Analysis: 13 lectures, 1 tutorial and 3 discussions)
My general area of research is in evolutionary genetics, which is concerned with the application of classical and molecular genetics to the study of evolution and natural variation. My group carries out both theoretical and experimental research, using theoretical ideas to motivate the experiments, and experimental data as stimulant for the development of theory. My recent research has focussed on three main areas: molecular evolution and variation, the evolution of genetic and sexual systems, and the quantitative genetics of life-history traits. Each of these areas illuminates the others. I am currently especially interested in the nature of the evolutionary process in genomes or genomic regions with low rates of genetic recombination, and am using theoretical models and studies of DNA sequence evolution and variation to study this problem. I am also interested in the problem of estimating the extent and intensity of selection on non-synonymous, synonymous and non-coding mutations.
Sanchez-Gracia, A. Maside, X. & Charlesworth, B. (2005). High rate of horizontal transfer of transposable elements in Drosophila. Trends in Genetics 21: 200-203.
Haddrill, P.R., Charlesworth, B., Halligan, D.L. & Andolfatto, P. (2005). Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content. Genome Biology 6:R67.
Loewe, L., Charlesworth, B., Bartolom & V. Nol, V. (2006). Estimating selection on nonsynonymous mutations. Genetics 172: 1079-1092.
Dolgin, E.S. & Charlesworth, B. (2006). The fate of transposable elements in asexual populations. Genetics 174: 817-827.
Cutter, A.D. & Charlesworth, B. (2006). Selection intensity on preferred codons correlates with overall codon usage bias in Caenorhaditis remanei. Curr. Biol. 16: 2053-2057.
Bartolome, C. & Charlesworth, B. (2006). Evolution of amino-acid sequences and codon usage on the Drosophila miranda neo-sex chromosomes. Genetics 174: 2033-2044.
Loewe, L. & Charlesworth, B. (2007). Background selection in single genes may explain patterns of codon bias. Genetics 175: 1381-1393.
Haddrill, P.R., Halligan, D.L., Tomaras, D. & Charlesworth, B. (2007). Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over. Genome Biology 8: R18
Charlesworth, B., Miyo, T. & Borthwick, H. (2007). Selection responses of means and inbreeding depression for female fecundity in Drosophila melanogaster suggest contributions from intermediate-frequency alleles to quantitative trait variation. Genet. Res. 89: 85-91.
Berlin, S., Tomaras, D. & Charlesworth, B. (2007). Low mitochondrial variability in birds may indicate Hill-Robertson effects on the W chromosome. Heredity 99: 389-396.
Elements of Evolutionary Genetics