Paper from Ohkura Lab features in JCB podcast
14th January 2016
The following paper from the Ohkura Lab was featured in a JCB podcast: "How catastrophes help oocytes avoid disaster."
A. Agata Głuszek, C. Fiona Cullen, Wenjing Li, Rachel A. Battaglia, Sarah J. Radford, Mariana F. Costa, Kim S. McKim, Gohta Goshima, and Hiroyuki Ohkura (2015) The microtubule catastrophe promoter Sentin delays stable kinetochore–microtubule attachment in oocytes. J. Cell Biol. 211 (6) 1113–1120
During meiosis, oocytes must attach homologous chromosomes to opposite spindle poles, but the cells take several hours to assemble a bipolar spindle. Gluszek et al. reveal that, in Drosophila oocytes, the microtubule catastrophe–promoting protein Sentin delays the formation of stable kinetochore–microtubule attachments until spindle assembly is complete, thereby preventing homologous chromosomes from incorrectly attaching to the same spindle pole.