Biological Sciences

Events and seminars

Monday Seminar Series - "Patterning the cytoplasm during asymmetric cell division"

Dr Erik Griffin - Department of biological Sciences, Dartmouth

21st February 2022 at 12:00pm [Download iCalendar / .ics file]

Daniel Rutherford Building, G.27 Lecture Theatre 1

MAX ATTENDANCE 50 - STRICT SIGN-UP IN PLACE AND WILL BE RELEASED ON THE MORNING OF THE SEMINAR TO AVOID PEOPLE SIGNING UP IN ADVANCE AND NOT ATTENDING. PLEASE ONLY SIGN-UP IF YOU CAN DEFINITELY ATTEND IN PERSON.

SEMIANR WILL ALSO BE LIVE STREAMED ON COLLABORATE - EMAIL LOUISE.BISHOP@ED.AC.UK FOR JOINING LINK.

Cell polarity is a hallmark of most cells and is the foundation for essential processes including asymmetric cell division and the formation of epithelia. To polarize, cells often rely on cellular scaffolds that restrict the localization of otherwise dynamic molecules. For example, it is known that many proteins polarize by binding to the plasma membrane/cell cortex in one half of the cell. Strikingly, relatively little is known about how asymmetries form in the cytoplasm.

During the asymmetric division of the C. elegans zygote, conserved cortical polarity regulators (the PAR proteins) orchestrate a dramatic partitioning of RNA-binding proteins into opposing cytoplasmic domains. In my talk, I will present our unpublished findings that the endoplasmic reticulum is a scaffold underlying these cytoplasmic asymmetries. Additionally, I will describe the central role of PLK-1 kinase, a conserved regulator of mitotic progression, in connecting cortical polarity cues to the partitioning of the cytoplasm.

Host Dhanya Cheerambathur

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