Monday Seminar Series - "Cell Economics: The Interplay Between Growth and Gene Expression in Bacteria"
Dr Jose Jimenez - SynBio, University of Surrey
9th March 2020 at 12:15pm [Download iCalendar / .ics file]
Daniel Rutherford Building, G.27, Lecture Theatre
The cellular resources required for gene expression are limited in bacterial cells. Owing to this, the expression of a particular gene can affect the activity of another seemingly unconnected gene and the extent of these couplings largely depends on the interplay between growth and gene expression. We combine experimental work and mathematical models to understand the molecular basis of the complex interactions derived from the allocation of cellular resources for gene expression. In particular, we have investigated the effect of producing partitions of ribosomes that can be allocated differentially to specific mRNAs of interest and exploited the tradeoffs between growth and phenotypic diversity with the final goal of improving the performance and predictability of synthetic genetic circuits and pathways.
Host Jack Suitor (PhD student)
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