WT PhD Programme Seminar - Deciphering (de)regulation of gene expression in health and disease using integrative omics approaches
Michiel Vermeulen - Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
23rd May 2018 at 12:00pm [Download iCalendar / .ics file]
Daniel Rutherford Building, G.27, Lecture Theatre 1
The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab is using state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in (differentiated) stem cells. In my lecture I will give an overview of current projects related to this topic.
Host PhilippVoigt and Elana Bryan
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