Biological Sciences

Licensing

Innovative tools and technologies available for commercial development.

Lab research

The quality of our research is reflected in the technologies and other intellectual property currently available for licensing or collaborative research and development.

Reagents and antibodies

Improved 'humanised' mouse models

A genetic engineering strategy in mouse embryonic stem cells to replace large regions of mouse chromosomal sequences (>100kb) with the corresponding human syntenic region.

Monoclonal antibody to streptavidin-binding protein

A monoclonal antibody to the streptavidin-binding epitope tag widely used in affinity purification of proteins.

Analysing the methylation status of human genes

Novel CGI-enrichment technology using two protein domains that isolate methylated and non-methylated CpG islands (CGIs).

Live attenuated Salmonella for vaccine development

Our method of producing safer, more effective, live attenuated Salmonella bacterial vaccines could be applied to the development of better vaccines for this and other infectious diseases.

Stem cells

Defined media for culturing regionalised anterior endoderm cells

Our defined media and serum-free process for isolating anterior definitive endoderm cells from mouse embryonic stem cells could improve the derivation of key gut-associated organ cells and provide a new set of gene profiling markers for directed differentiation.

Haematopoietic stem cell expansion

A method for producing large quantities of haematopoietic stem cells from tissues in the laboratory that could potentially be used to treat a wide variety of blood disorders and cancers.

Non-viral method for creating induced pluripotent stem cells

Our safer, non-viral plasmid vector for generating induced pluripotent stem cells by introducing the four genes required for reprogramming of somatic cells in a single fragment; the genes can be removed following reprogramming.

MBD3-deficient embryonic stem cell line

A pluripotent (murine) embryonic stem cell line, which can be maintained in the absence of any exogenous factors and stimulated to differentiate into identifiable bone, muscle, skin, fat and neuronal tissue.