A longitudinal prospective study of the development of bipolar disorder (and depression) in 250 individuals at high or low genetic risk of bipolar disorder.
The high risk subjects come from multiply affected families, and all have a minimum of least one first degree relative affected with bipolar disorder. We expect that approximately 10% of the high risk sample will develop bipolar disorder over the course of the study, with a larger number developing clinical depression.
All participants have been studied twice over an approximately 18-24 month interval with detailed clinical, neuropsychological and neuroimaging assessments. Brain imaging includes high resolution structural MRI, two fMRI paradigms (Hayling sentence completion task and Ekman faces) and DTI. The study has therefore acquired an unequalled amount of data on people at high genetic risk of bipolar disorder and in healthy controls during late adolescence / early adulthood.
The baseline brain imaging studies have already demonstrated that:
This article was published on Oct 17, 2011