Dr Steven Watterson
Mathematical Modeller, Ghazal Group
I am interested in the mathematical modelling of signalling pathways.
Research Interests
We have studied a range of approaches to modelling signalling pathways. At present, we are using Boolean logic, exploiting its simplicity to allow us to calculate the properties of large scales of pathways.
Inference of signalling pathways from biological data. Finding a suitable modelling approach is the first step to being able to infer the details of signalling pathways from experimental data. We are studying the process of inference for the properties and parameters of signalling pathways using microarray data.
Publications
Mathieu Blanc, Wayne Hsieh, Kevin A Robertson, Steven Watterson, Guanghou Shui, Paul Lacaze, Mizanur Khondoker, Paul Dickinson, Garwin Sing, Sara Rodríguez-Martín, Peter Phelan, Thorsten Forster, Birgit Strobl, Matthias Müller, Rudolph Riemersma, Timothy Osborne, Markus R Wenk, Ana Angulo, Peter Ghazal (2011) Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis PLoS Biology (in press)
Laurence Loewe, Maria Luisa Guerriero, Steven Watterson, Stuart Moodie, Peter Ghazal, Jane Hillston (2011) Translation from the Quantified Implicit Process Flow Abstraction in SBGN-PD Diagrams to Bio-PEPA Illustrated on the Cholesterol Pathway Trans. on Comput. Syst. Biol. XIII (C. Priami et al. Eds.), LNBI (Springer) 6575: 13—38
Peter Ghazal, Steven Watterson, Kevin Robertson, David Kluth (2011) The in silico macrophage: toward a better understanding of inflammatory disease Genome Medicine 3: 4. Jan
Sobia Raza, Neil McDerment, Paul Lacaze, Kevin Robertson, Steven Watterson, Ying Chen, Michael Chisholm, George Eleftheriadis, Stephanie Monk, Maire O’Sullivan, Arran Turnbull, Douglas Roy, Athanasios Theocharidis, Peter Ghazal, Tom Freeman (2010) Construction of a large scale integrated map of macrophage pathogen recognition and effector systems BMC Systems Biology 2010, 4:63 4: 63. May
Steven Watterson, Peter Ghazal (2010) Use of logic theory in understanding regulatory pathway signaling in response to infection Future Microbiology 5: 2. 163-176 February
Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie, Falk Schreiber, Anatoly Sorokin, Emek Demir, Katja Wegner, Mirit Aladjem, Sarala Wimalaratne, Frank Bergman, Ralph Gauges, Peter Ghazal, Hideya Kawaji, Lu Li, Yukiko Matsuoka, Alice Villéger, Sarah Boyd, Laurence Calzone, Melanie Courtot, Ugur Dogrusoz, Tom Freeman, Akira Funahashi, Samik Ghosh, Akiya Jouraku, Sohyoung Kim, Fedor Kolpakov, Augustin Luna, Sven Sahle, Esther Schmidt, Steven Watterson, Guanming Wu, Igor Goryanin, Douglas Kell, Chris Sander, Herbert Sauro, Jacky Snoep, Kurt Kohn, Hiroaki Kitano (2009) The Systems Biology Graphical Notation Nature Biotechnology 27: 735-741
Le Yu, Steven Watterson, Stephen Marshall, Peter Ghazal (2009) Inference of transition probabilities between the attractors in Boolean networks with perturbation In: Genomic Signal Processing and Statistics, 2009. GENSIPS 2009. IEEE International Workshop
Steven Watterson (2008) The chiral and flavour projection of Dirac-Kahler fermions in the geometric discretization International Journal of Geometric Methods in Modern Physics 5: 3. 1-18 May
Steven Watterson, Stephen Marshall, Peter Ghazal (2008) Logic models of pathway biology Drug Discovery Today 13: 9/10. 447-456 May
Le Yu, Steven Watterson, Stephen Marshall, Peter Ghazal (2008) Inferring Boolean Networks with perturbation from sparse gene expression data: a general model applied to the Interferon regulatory network Molecular BioSystems 4: 1024 - 30
Steven Watterson (2008) The chiral and flavour projection of Dirac-Kahler fermions in the geometric discretization International Journal of Geometric Methods in Modern Physics 5: 3. 1-18 May
Steven Watterson, Stephen Marshall, Peter Ghazal (2008) Logic models of pathway biology Drug Discovery Today 13: 9/10. 447-456 May
Le Yu, Steven Watterson, Stephen Marshall, Peter Ghazal (2008) Inferring Boolean Networks with perturbation from sparse gene expression data: a general model applied to the Interferon regulatory network Molecular BioSystems 4: 1024 - 30
Steven Watterson (2007) The Flavour projection of staggered fermions and the quarter-root trick. Journal of High Energy Physics 2007: 06. 048
Steven Watterson, James Sexton (2005) Distributing the chiral and flavor components of Dirac-Kahler fermions across multiple lattices. In: Proceedings of 23rd International Symposium on Lattice Field Field: Lattice 2005, Trinity College, Dublin, Ireland, 25-30 Jul 2005. Edited by:Alan Irving, Craig McNeile, Chris Michael. Proceedings of Science.
This article was published on Jul 19, 2012