I am interested in making use of statistical meta-analysis techniques in high-throughput genomic platforms, specifically, microarray data for studies covering interferon pathways in macrophages.
Project title: Statistical meta-analysis of microarray platform data related to immune response
The idea underlying my project is that individual biological studies (microarray gene expression and others) are frequently too small and underpowered to deliver conclusive results.
Combining the statistical results from multiple studies allows us to identify pathway genes with higher sensitivity and specificity.
The output of this research is refined biological knowledge that finds its way into further downstream analyses, such as input nodes for graph theoretical approaches to gene regulatory networks.
This article was published on May 15, 2013