This competition is now closed. The successful applicants will be contacted before end of February .
The project, jointly led by Professor Peter Ghazal and Dr Simon Talbot, will focus on dissecting the physiological role for the sterol pathway as part of a host protection pathway acting against infection. An aim of the project is to highlight the potential for pharmacological targeting of host metabolic regulatory networks as an anti-viral strategy.
Microbial antibiotic resistance is one of the biggest threats to healthcare. This project will research the impact on antibiotic therapy on the molecular host-pathogen interaction and the survival of bacterial pathogens in the host. Increased understanding of this scenario will help designing more specific therapies in the context of a personalised medicine approach in infectious diseases. The project is led by Dr Till Bachmann and Professor Peter Ghazal.
This project (co-supervised by Professors Juergen Haas and Peter Ghazal) will investigate the function of anti-viral, cellular proteins that have recently been identified in genome-scale RNA interference screens, with Herpes Simplex virus (HSV) and Varicella Zoster virus (VZV). All herpesviruses, including HSV and VZV, cause latent infections (in neuronal cells) and can reactivate and cause active disease if insufficiently controlled by the host immune system. These studies will explore how these antiviral subunits act on viral replication, and their potential as candidates for drug development.
The studentship will be for three years and will offer UK/EU tuition fees, annual stipend IRO £13.6k, and bench fees. The closing date for applications is 1 February 2012.
Before submitting an application, we recommend contacting the PIs responsible for the projects
Please mark your application "MRC-DPM".
We are pleased to receive enquiries from well-qualified funded students interested in pursuing PhD research with us.
The DPM conducts a wide range of research projects in a number of areas.
Before submitting an application, please contact the academic staff member with expertise relevant to your intended area of research.
Informal enquiries can be made to Dr Douglas Roy.
This article was published on Feb 3, 2012