A simple test to identify MRSA in wounds could identify the superbug quickly and help prevent infection from spreading.
Researchers at the Division of Pathway Medicine and the Schools of Physics and Chemistry have developed the test to show whether wounds or lesions are infected with bacteria and if MRSA is present.
The test, developed at the University of Edinburgh in collaboration with NHS Lothian, works by taking swabs from a wound or sores, which are then analysed using a strip with electrical sensors that can detect MRSA.
The collaboration was led by Dr Till Bachmann, Professor Jason Crain, Professor Peter Ghazal, Professor Anthony Walton, Dr Andy Mount & Dr Colin Campbell from the University of Edinburgh and Dr Matthew Young, Dr Kate Templeton and Dr Paddy Gibb from NHS Lothian.
Antibiotic resistance is becoming a pressing issue in modern healthcare and we are in serious danger of entering a post-antibiotic era. Current tests for MRSA tend to be expensive and not very fast. By developing a rapid and cost-effective test, we would know what kind of infection is present straight away, which will improve the chance of success in treating it
Dr Till Bachmann
COO and Head of Biochip Research, Division of Pathway Medicine
Researchers currently process the swab samples in the laboratory to increase the amount of bacteria present before testing them, but hope to avoid the need for this in the future by improving the strip’s sensitivity.
This would enable scientists to develop a test that could be used outside the laboratory, for example in GP practices or people’s homes.
The ability to detect the bacteria more quickly than with conventional tests would enable more effective drugs to be given to the patient straight away.
Currently, laboratory tests to confirm whether MRSA is present in a wound can take a full day using conventional techniques.
The test was developed using swabs from diabetic foot ulcers taken from patients attending NHS Lothian’s Diabetic Foot Clinic at the Royal Infirmary of Edinburgh.
Detection of MRSA in these patients is important to prevent the spread of infection, which can lead to the amputation of limbs and increase the risk of mortality.
Dr Till Bachman, from the University of Edinburgh’s Division of Pathway Medicine, will present the research behind the test today (Thursday, March 29) at the Advances in Biodetection and Biosensors conference in Edinburgh.
Edinburgh scientists are using similar technology to monitor signals that bacteria send to each other to spread infections, and chemicals that patients produce that indicate the wound’s response to the infecting bacteria. Understanding why bacteria release certain molecules as part of this process will help scientists identify the start of an infection and so treat it promptly.
The development of the test, funded with £2.26 million from Scottish Enterprise’s Large Scale Research and Development Programme, involved input from the University of Edinburgh’s Division of Pathway Medicine, School of Chemistry, School of Physics and Astronomy and the Scottish Microelectronics Centre working with NHS Lothian’s Diabetic Foot Clinic and Microbiology Department.
This article was published on Apr 10, 2012