Understanding how human neonates respond to infection remains incomplete. This systems pathway-biology investigation of neonatal systemic responses to infection shows a surprisingly strong but unbalanced homeostatic immune response; developing an elevated set-point of myeloid-regulatory-signaling and sugar-lipid metabolism with concomitant inhibition of lymphoid responses. Innate-immune negative feedback opposes innate-immune activation while suppression of T-cell co-stimulation is coincident with selective up-regulation of CD85 co-inhibitory pathways. Examining modules of co-expressed RNA in symptomatic neonates we identify a limited set of networks associated with bacterial infection that exhibit high levels of inter-patient variability. By integrating immune and metabolic pathways we infer a patient-invariant 52-gene-classifier that predicts bacterial infection with high accuracy using a new independent patient population. This is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests. Our results lay the foundation for future translation of host-pathways in advancing diagnostic, prognostic and therapeutic strategies for neonatal-sepsis.
Congratulations to the ICONZ team based in the Division of Pathway Medicine, who had three papers published in the May edition of PLOS Neglected Tropical Diseases.
ICONZ is an EU-funded project that aims to improve human health and animal production in developing countries through Integrated Control of Neglected Zoonoses in animals, based on scientific innovation and public engagement.
Congratulations to Dr Samantha Griffiths, Senior Research Fellow in the DPM, who received the 2014 EUSA Teaching Award for Best Project Dissertation Supervisor. Sam, who was accompanied by some of her students, accepted the award at the ceremony last night (23 April) in Teviot Row House.
Dr Till Bachmann and Dr Kate Templeton will present at the ESCMID Postgraduate Education Course "Principles of Molecular Microbiological Diagnostics" in Maastricht on Wednesday 5th March.
The course provides an overview of the general principles of state-of-the-art molecular techniques for diagnosis of infectious diseases: Quantitative PCR, (Next-Generation) Sequencing and Mass Spectrometry. In addition, the course educates participants on the set-up, validation and quality control of the different techniques and discusses the latest and upcoming developments in the field.
A project, led by Professor Sue Welburn, aimed at eradicating sleeping sickness in Uganda has secured a prestigious award.
Stamp Out Sleeping sickness (SOS) is a collaborative campaign involving students and experts from the University of Edinburgh who are working in close partnership with colleagues from the University of Makerere in Uganda. Their efforts have been recognised by the Ugandan government, which has bestowed the “Collaboration and Networking across Government Award”.
The SOS campaign is tackling what is one of Africa’s biggest public health challenges. Health professionals are battling to prevent the two types of sleeping sickness prevalent in Uganda - acute and chronic - from converging. Doctors fear that if the two forms merge, the diseases will be impossible to treat with drugs that are currently available to them.
We wish to appoint a new Lecturer to support teaching and research in the School of Biomedical Sciences in the area of Medical Microbiology. The post-holder will be expected to develop, deliver and assess undergraduate and postgraduate courses and contribute to the academic administration of teaching activities. Individuals will be expected to deliver an independent research programme that complements research priorities within the School of Biomedical Sciences, as evidenced by publications in leading international peer-reviewed journals and the ability to obtain external grant funding.
This post is aimed at early career individuals of the highest potential who have begun to establish a reputation for quality research in the field of Medical Microbiology and who have a proven commitment to university level learning and teaching.
For further information about the post and the application process please go the the University 'Jobs website.
The University of Edinburgh, a global top 20 University located in one of the world‘s finest cities, continues to invest in the future of its academic staff with the appointment of a cohort of 50 tenure-track Chancellor’s Fellowships across all disciplines. These 5-year Fellowships are intended to support candidates at the start of their independent academic careers. Subject to satisfactory review at the end of year 3, the Fellow will then move to a standard University academic open-ended contract. It is anticipated that most appointees will be successful in obtaining an open ended contract.
For more information on these fellowships and application details please go to the university Jobs website.
A series of public lectures examining the global challenges facing society, and the role of academia in meeting these challenges. Delivered by distinguished speakers the talks focus on the contribution academia can make to understanding and addressing these global challenges.
For more more information on the series, visit the Our Changing World website.
ClouDx-i is a major research project concerned with developing host pathogen response biomarkers for infection and is funded under the EU FP7 Marie Curie Actions IAPP program.
We are seeking a More Experienced Researcher (MER > 10 yrs experience since primary degree) on the ClouDx-i project for a fixed-term 13 month assignment, starting approximately September 2013. This project aims to develop in silico molecular detection methods to flag biomarkers that can facilitate rapid, efficient and accurate diagnosis of infection. Owing to EU “mobility” regulations, applications cannot be considered either from UK nationals or from candidates who have spent more than 12 of the 36 months preceding the start of their employment contract in the UK. UK fellows based in the UK will be considered provided that they were based in another country for at least 24 of the 36 months preceding their recruitment for this position.
For further information please contact Dr Paul Walsh (see DPM contacts) or click on link to Jobs web page.
A paper authored by members of DPM and the Schools of Physics and Chemistry has been awarded the "International Journal of Molecular Science Best Paper Award" for 2013.
Flourescence Lifetime Imaging of Quantum Dot Labeled DNA Microarrays has been selected from 174 papers published in 2009 as "the most outstanding".
Giraud G, Schulze H, Bachmann TT, Campbell CJ, Mount AR, Ghazal P, Khondoker MR, Ross AJ, Ember SW, Ciani I, Tlili C, Walton AJ, Terry JG, Crain J, Fluorescence Lifetime Imaging of Quantum Dot Labeled DNA Microarrays. Int. J. Mol. Sci. 2009, 10(4), 1930-1941.
The following paper has been accepted for publication in the Journal of the American Chemical Society:
J Am Chem Soc. 2013 Mar 6.
Cyclic denaturation and renaturation of double stranded DNA by redox- state switching of DNA intercalators.
Syed SN, Schulze H, Macdonald D, Crain J, Mount AR, Bachmann TT.
On Tuesday 5th February 2013 Scotland's First Minister, Alex Salmond, visited the Edinburgh Bioquarter to see the work being carried out there and to announce the opening of three new specialist research companies - Science Squared, R-Biomedical and Marks and Clerks - at the research campus.
The First Minister heard from Dr Till Bachmann, DPM, working for Mölnlycke Health Care on a consultancy basis as Scientific Program Director, about the potential of a point of care test originally developed as part of the Scottish Enterprise Chronic Wound Care project led by DPM and conducted by researchers at the University of Edinburgh and NHS Lothian.
Further development is now taking place as part of a collaboration between Mölnlycke Health Care and the University of Edinburgh.
Follow the link for more information about the collaboration and links to an article in The Scotsman and to footage of Dr Bachmann, Russell McCraith, MD of MHC Scotland, and the First Minister.
Intimate connections between the workings of the immune system and cholesterol metabolism in fighting against infection.
A multinational collaborative effort, including researchers from UK, USA, Singapore, Germany, and Spain, and led by Professor Peter Ghazal and co-workers Mathieu Blanc and Wei Yuan Hsieh in the Division of Pathway Medicine, have found that in response to infection, white blood cells secrete a copious amount of a specifically modified cholesterol metabolite that acts as a potent inhibiter of viral growth. This metabolite (an oxysterol) lowers cholesterol level in the cell that is essential for viral growth.
The work uncovers a direct link between the workings of the immune system and cholesterol metabolism. Armed with this information researchers are pursuing this as a powerful new way of controlling cholesterol levels to fight against infection and heart disease.
As part of a series of events for German-speaking academics, the German Consulate in Edinburgh will co-host a networking event with Dr Till Bachmann, DPM, in the Playfair Library, Old College, on Thursday 7th February 2013.
The objective is to encourage closer ties between the many German academics working at further and higher education institutes within the consular district, as well as increase contact with the Consulate.
The Consulate would like to give German academics the opportunity to get to know one another and exchange experiences and best practices. In addition to academic topics, this could include more general questions about living and working in Scotland/Northern Ireland as a German academic, as well as Children's education, finding work for your partner and consular queries.
Please note the date in your diary. Invitations will follow in due course. Naturally, German speaking academics from other countries are also warmly invited.
Dr Till Bachmann, DPM, has been appointed to the Scientific Advisory Board of the BDI - Biomedical Diagnostics Institute - in Dublin.
The inaugural meeting of the Board took place in Dublin City University on 11th and 12th of October 2012.
Members of DPM and the Robert Koch Institue have published their research on the combination of a new KPC-microarray with commercial sample preparation for the detection and genotyping of microbial pathogens directly from clinical specimen.
Peter H, Berggrav K, Thomas P, Pfeifer Y, Witte W, Templeton K, Bachmann TT. Direct Detection and Genotyping of KPC Carbapenemases from Urine using a new DNA Microarray Test. Journal of Clinical Microbiology 2012. 10.1128/JCM.00990-12
These studies provide, for the irst time, evidence for a role of IE1 as a regulator of the pro-inflammatory response and demonstrate a specific pathogen gene capable of moderating the host production of TNFα in vivo.
New studies published in Biochimie today provide fresh discoveries about how our bodies regulate cholesterol levels. This paper shows that the immune system tunes down cholesterol production in order to fight viral infection, which leads us to ask whether we can manipulate the way that cells produce cholesterol to help fight the spread of viral infections.
A simple test to identify MRSA in wounds could identify the superbug quickly and help prevent infection from spreading.
Researchers from the Division of Pathway Medicine and the Schools of Physics and Chemistry have developed the test to show whether wounds or lesions are infected with bacteria and if MRSA is present.
Congratulations to Dr Douglas Roy, as the Division of Pathway Medicine has again been nominated for an Edinburgh University Student's Association Teaching Award 2011/12.
Congratulations to Professor Susan Welburn on her appointment as Assistant Principal Global Health, responsible for progressing the University's strategic objectives and developing University policy.
Scientists led by Dr Colin Campbell, Division of Pathway Medicine & School of Chemistry, University of Edinburgh, have created a sensor that measures tiny electronic signals in cells that help keep the cell functioning and are a key indication of health.
This article was published on Aug 14, 2014