My work focuses on the role of Pax6 in the adult cornea. Low levels of Pax6 expression in Pax6+/- mice and patients with aniridia cause abnormal eye development and progressive corneal deterioration after birth. We hypothesise that Pax6 has multiple roles in adult corneal homeostasis. Some aspects of adult corneal deterioration may be predetermined by abnormal development while other may reflect low levels of Pax6 in the adult. We are investigating this by manipulating Pax6 levels to a) determine how reduced Pax6 levels cause corneal abnormalities and b) to identify the role of Pax6 in corneal maintenance in the adult.
Chanas SA, Collinson JM, Ramaesh T, Dorà N, Kleinjan DA, Hill RE, West JD (2009). Effects of elevated Pax6 expression and genetic background on mouse eye development. Invest Ophthalmol Vis. Sci. 50(9): 4045-59
Dorà N, Ou J, Kucerova R, Parisi I, West JD, Collinson JM (2008). Pax6 dosage effects on corneal development, growth and wound healing. Dev Dyn. 237(5):1295-306
Fowler PA, Dorà NJ, McFerran H, Amezaga MR, Miller DW, Lea RG, Cash P, McNeilly AS, Evans NP, Catinot C, Sharpe RM, Rhind SM (2008). In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep. Mol. Hum. Reprod. 14(5):269-80
This article was published on Sep 17, 2010