Dr Lynn Powell
- Dr Lynn Powell
- Postdoctoral Research Fellow
- Jarman Lab
- Hugh Robson Building
- George Square
- Edinburgh
- EH8 9XD
- Work: 0131 650 3182
- Email:
- Lynn.powell@ed.ac.uk
Personal profile
- Present: Senior Postdoctoral Research Fellow, Professor Andrew Jarman’s lab, Centre for Integrative Physiology, University of Edinburgh
- 1990-2000: Postdoctoral Research Fellow, Professor Noreen Murray’s lab, Institute of Cell and Molecular Biology, University of Edinburgh
- 1986-1990: PhD, Professor Roger Pain’s laboratory, Department of Biochemistry, University of Newcastle upon Tyne
Research
My work focuses on the role of posttranslational modification in the regulation of transcriptional activation by the proneural proteins.
The Drosophila proneural proteins are basic helix-loop-helix transcription factors essential for the specification of neural precursors in the peripheral nervous system.
Mammalian homologues also have key roles in neural development. For example, Atoh1 is essential for the formation of inner ear hair cells while Atoh7 is essential for retinal ganglion cell development. In addition Atoh1 has recently been shown to be a tumour suppressor gene.
My work focuses on dissecting the molecular mechanisms governing interactions between the proneural proteins and regulatory factors with a particular focus on posttranslational modification.
Funding
- The Wellcome Trust
Collaborations
- Dr Angela Chen, Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
Selected publications
Powell, L.M. & Jarman, A.P. (2008). Context dependence of proneural bHLH proteins. Curr. Opin. Genet. Dev. 18 (5) : 411-7.
Powell, L.M., Deaton, A.M., Wear, M.A. and Jarman, A.P. (2008). Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless. Genes to Cells 13 (9): 915-29.
zur Lage, P.I., Powell, L.M., Prentice, D.R.A., McLaughlin, P. & Jarman, A.P. (2004). EGF receptor signalling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation. Dev. Cell (2004) 7 (5) 687-96.
Powell, L.M., zur Lage, P.I., Prentice, D.R.A., Senthinathan, B. and Jarman, A.P. (2004). The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol. Cell. Biol. 24, Issue 21 (9517-26).
This article was published on Jul 6, 2011