Dr Guisy Pennetta

Dr Guisy Pennetta Lecturer
Centre for Integrative Physiology
Euan MacDonald Centre for Motor Neurone Disease Research
Hugh Robson Building
George Square
Edinburgh, EH8 9XD
Work: +44 (0)131 651 3201

We are studying the molecular mechanisms underlying Amyotrophic Lateral Sclerosis (ALS).

Personal profile

  • Post-doctoral fellow, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, US
  • PhD, University of Geneva (Switzerland)
  • BSc, University of Bari (Italy)


Motor Neuron Diseases (MNDs) including Amyotrophic Lateral Sclerosis (ALS) were first identified more than 130 years ago but our understanding on what causes these devastating diseases is still rudimentary.

Such poor understanding hinders the development of therapies that at the moment do not seem to be very effective.

MNDs encompass a group of inherited disorders characterized by selective dysfunction and death of motor neurons leading to spasticity, muscle atrophy and paralysis.

Over the last decade, a growing number of neurodegenerative diseases, including polyglutamine diseases, Parkinson’s disease and tau-associated pathologies, have been modelled in the fruitfly Drosophila melanogaster.

Why study human neurodegeneration in flies?

Their small size, rapid generation time and low cost for maintenance as compared to mammalian models, have made them an attractive system.

Recently, we have generated a “fly model” for Amyotrophic Lateral Sclerosis (ALS) and we intend to use it to elucidate the molecular mechanisms underlying ALS.

We are confident that a better understanding of the molecular mechanisms responsible for the pathogenesis will open up the possibility to identify new targets for an effective therapeutic intervention.

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  • The Wellcome Trust
  • Motor Neurone Disease Association
  • Scottish Motor Neurone Disease Association

Team members

  • Stewart Forrest
  • Manuela Marescotti
  • Raquel Mendez-Castro
  • Evangelia Tasouri


  • Vivian Budnik,University of Massachusetts Medical School,Worcester, US
  • Bing Zhang, University of Oklahoma, Norman, US
  • Jackie deBelleroche, Imperial College London, UK


Lloyd, T.E., Atkinson, R., Wu, M.N., Zhou, Y., Pennetta, G. and Bellen, H.J. (2002) Hrs regulates endosomal maturation and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-269.

Pennetta, G., Hiesinger, P.R., Fabian-Fine, R., Meinertzhagen, I.A. and Bellen, H. J. (2002). Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage- dependent manner. Neuron, 35: 281-306 (Cover).

Chai, A., Withers, J.P.J., Koh, Y.H., Zhang, B., Budnik, V., Pennetta, G. (2008). hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the Neuromuscular Junction. Human Molecular Genetics 17: 266-280.

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