Research focus
We aim to understand how molecular traffic across membranes is coordinated in space and time, and how disruptions in this process may lead to disease.
The Membrane Biology Group (MBG) exploits a variety of real time imaging, electrophysiological and cell/molecular biochemical approaches.
We have extensive expertise in the analysis of molecular traffic across membranes (via either channels, transporters or vesicles).
Information from these studies is now being integrated across different physiological systems to address the challenge of determining the spaciotemporal dynamics of molecular traffic and cellular communication.
This is being achieved through the exploitation of state of the art real-time, quantitative imaging tools, in concert with genetically encoded reporters.
This allows a detailed analysis both intra- and inter-cellular traffic at both the systems and model organism level, providing key information on the integration of cellular communication in both the nervous and endocrine systems.
Areas of interest
We publish short briefing papers about our areas of interest.
- Regulation of Neurotransmitter Secretion (PDF)
- Synaptic Cell Biology (PDF)
- Cotransporters and hypertension (PDF)
- Neuronal vulnerability in neurodegenerative disease (PDF)
- Chondrocytes, osteoarthritis and bone growth (PDF)
- NMDA receptor control of neuronal survival and death (PDF)
- Postranscriptional regulation of ion channel physiology (PDF)
- Molecular mechanisms of neurodegeneration (PDF)
See our staff profiles for more detailed information about their research projects.
This article was published on Mar 30, 2010