People
Prof. Rose ZamoyskaLocation: Room 2.57, 2nd floor, Ashworth Labs. ext. 2 | |
C.V.
| Year | Description |
|---|---|
| 1981 | PhD in Immunology, Department of Pathology, University of Cambridge. |
| 1981 1984 | Postdoctoral Research Assistant, Department of Pathology, University of Cambridge. |
| 1984 1987 | Postdoctoral Research Fellow, Dept. of Medicine, Stanford University, U.S.A. |
| 1987 1991 | Research Scientist, ICRF, Tumour Immunology Unit, University College London. |
| 1991 2007 | Senior Research Scientist, MRC National Institute for Medical Research, Mill Hill, London. |
| 2007 Present | Professor of Immune Cell Biology, University of Edinburgh. |
Research interests
We are interested in understanding how T lymphocytes communicate with their environment both during differentiation in the thymus and subsequently in the periphery to regulate survival, expansion and further differentiation into effector or memory cells, while maintaining tolerance.
Representative publications
- Seddon, B., G. Legname, P. Tomlinson and R. Zamoyska (2000) Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56lck. Science 290: 127-131.
- Seddon, B., P. Tomlinson and R. Zamoyska (2003) Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4: 680-686.
- Zamoyska, R., A. Basson, A. Filby, G. Legname, M. Lovatt and B. Seddon (2003) The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol. Rev. 191: 107-118.
- Lovatt, M., A. Filby, V. Parravicini, G. Werlen, E. Palmer and R. Zamoyska (2006) Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response. Mol. Cell. Biol. 26: 8655-8665.
- Filby, A., B. Seddon, J. Kleczkowska, R. Salmond, P. Tomlinson, M. Smida, J. A. Lindquist, B. Schraven and R. Zamoyska (2007) Fyn regulates the duration of TCR engagement needed for commitment to effector function. J. Immunol. 179: 4635-4644.
This article was published on Feb 8, 2012