People
Dr Ramon GrimaLocation: C. H. Waddington Building Room 3.03 |  |
C.V.
| Year | Description |
|---|---|
| 2008 - present | Lecturer, University of Edinburgh |
| 2006-2008 | Mathematical Institute Fellow, Imperial College London |
| 2005-2006 | Postdoctoral Fellow, School of Informatics, Indiana University, USA |
| 2005 | Ph.D Physics, Arizona State University, USA |
| 2002 | M.A. Physics, University of Virginia, USA |
| 2000 | B. Sc (Hons), Physics and Pure Mathematics, University of Malta, Malta |
Teaching
Quantification in Life Sciences (Course Director)
Structures and Functions of Proteins
Research interests
Most studies of stochastic biochemical phenomena in the literature are typically addressed via simulations; we take a different approach by developing novel approximate analytical methods which are in many cases computationally more efficient than simulations and which offer a global picture of the dynamics under study. A few approaches we have developed include novel forms of rate equations and chemical langevin equations to deal with conditions characterized by low to intermediate molecule numbers, and a novel form of the chemical master equation which is valid in non-well mixed crowded conditions. Other topics of interest include the development of rigorous methods to obtain low-dimensional descriptions of large reaction networks.
Representative publications
- Grima R., Thomas P. and Straube A. V. (2011). How accurate are the chemical Langevin and Fokker-Planck equations? J. Chem. Phys. 135: 084103
- Thomas P., Straube A. V. and Grima R. (2010). Stochastic theory of large-scale enzyme-reaction networks: finite-copy number corrections to rate equation models. J. Chem. Phys. 133: 195101
- Grima R. (2010). An effective rate equation approach to reaction kinetics in small volumes: theory and application to biochemical reactions in nonequilibrium steady-state conditions. J. Chem. Phys. 133: 035101
- Grima R. (2010). Intrinsic biochemical noise in crowded intracellular conditions. J. Chem. Phys. 132: 185102
- Grima R. (2009). Investigating the Robustness of the Classical Enzyme Kinetic Equations in Small Intracellular compartments. BMC Systems Biology 3:101
- Grima R. (2009). Noise-Induced Breakdown of the Michaelis-Menten Equation in Steady-State Conditions. Physical Review Letters 102: 218103
- Grima R. and Schnell S. (2008). Modelling reaction kinetics inside cells. Essays in Biochemistry 45: 41
- Grima R. and Schnell S. (2006). A Systematic investigation of the rate laws valid in intracellular environments. Biophysical Chemistry 124: 1
- Grima R. (2005). Strong coupling dynamics of a multi-cellular chemotactic system. Physical Review Letters 95: 128103
- Newman T. J. and Grima R. (2004). Many-body theory of chemotactic interactions. Physical Review E 70: 051916 (2004)
This article was published on Feb 8, 2012