Prof. Brian Charlesworth
Location: Floor 1, Ashworth Labs
Molecular Evolution and Genomics
Genomes and Genomics (3rd year): 3 lectures
My general area of research is in evolutionary genetics, which is concerned with the application of classical and molecular genetics to the study of evolution and natural variation. My group carries out both theoretical and experimental research, using theoretical ideas to motivate the experiments, and experimental data as stimulant for the development of theory. My recent research has focussed on three main areas: molecular evolution and variation, the evolution of genetic and sexual systems, and the quantitative genetics of life-history traits. Each of these areas illuminates the others. I am currently especially interested in the nature of the evolutionary process in genomes or genomic regions with low rates of genetic recombination, and am using theoretical models and studies of DNA sequence evolution and variation to study this problem. I am also interested in the problem of estimating the extent and intensity of selection on non-synonymous, synonymous and non-coding mutations.
Sanchez-Gracia, A. Maside, X. & Charlesworth, B. (2005). High rate of horizontal transfer of transposable elements in Drosophila. Trends in Genetics 21: 200-203.
Haddrill, P.R., Charlesworth, B., Halligan, D.L. & Andolfatto, P. (2005). Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content. Genome Biology 6:R67.
Loewe, L., Charlesworth, B., Bartolom頦 V. No묬 V. (2006). Estimating selection on nonsynonymous mutations. Genetics 172: 1079-1092.
Dolgin, E.S. & Charlesworth, B. (2006). The fate of transposable elements in asexual populations. Genetics 174: 817-827.
Cutter, A.D. & Charlesworth, B. (2006). Selection intensity on preferred codons correlates with overall codon usage bias in Caenorhaditis remanei. Curr. Biol. 16: 2053-2057.
Bartolome, C. & Charlesworth, B. (2006). Evolution of amino-acid sequences and codon usage on the Drosophila miranda neo-sex chromosomes. Genetics 174: 2033-2044.
Loewe, L. & Charlesworth, B. (2007). Background selection in single genes may explain patterns of codon bias. Genetics 175: 1381-1393.
Haddrill, P.R., Halligan, D.L., Tomaras, D. & Charlesworth, B. (2007). Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over. Genome Biology 8: R18
Charlesworth, B., Miyo, T. & Borthwick, H. (2007). Selection responses of means and inbreeding depression for female fecundity in Drosophila melanogaster suggest contributions from intermediate-frequency alleles to quantitative trait variation. Genet. Res. 89: 85-91.
Berlin, S., Tomaras, D. & Charlesworth, B. (2007). Low mitochondrial variability in birds may indicate Hill-Robertson effects on the W chromosome. Heredity 99: 389-396.
Elements of Evolutionary Genetics
This article was published on Feb 8, 2012