Prof. Rick Maizels
|1976||PhD in Immunology, National Institute for Medical Research, Mill Hill, London.|
|1976 1977||Postdoctoral training in Biology, California Institute of Technology.|
|1977 1979||Postdoctoral training in Microbiology, University of California at Los Angeles.|
|1979 1983||Scientific staff, Parasitology, National Institute for Medical Research.|
|1983 1995||Lecturer/Reader/Professor in Parasite Immunology, Biology Department, Imperial College.|
|1995 Present||Professor of Zoology, University of Edinburgh.|
Parasites which live in mammalian hosts for long periods have evolved an array of mechanisms for diverting and manipulating the host immune response. We are studying the interaction between nematode parasites and the immune system in order to understand parasite survival, to devise new means of shifting the balance towards protective immunity, and to isolate novel molecules from nematode parasites which modify immune responses.
Current projects include the role of Regulatory T cells (Tregs) and Th2 effector cells in modifying protective immunity; characterisation of secreted proteins which drive Regulatory T cell responses; dendritic cell populations in helminth infections; combining transcriptomic and proteomic analyses of parasite immunomodulatory genes; definition of the major T cell antigens in infection; use of transfection technologies to measure immune gene function; and the function of cytokine-like proteins encoded within parasite genomes.
This article was published on Oct 11, 2012