The research of principal investigators in IIIR encompasses four overlapping themes of study:
Fundamental Immunology research centres around how B and T lymphocytes interact and develop in response to antigen challenge, how responses are initiated by dendritic cells and dampened by regulatory cells. Specific interests include surface receptors and ligands involved in intercellular communication within the immune system, and the analysis of the role of each molecular and cellular component over time in vivo.
Studies on the Immune Regulation of Disease combine research into autoimmunity and parasite immunology. We study immune evasion by long-lived parasite pathogens (such as filarial nematodes), as well as the factors controlling immune pathologies such as autoimmune diseases and allergy. Projects aim to design immunological interventions to ameliorate pathology or to enhance host immunity, in conjunction with new vaccines against parasites.
The Molecular Biology and Genetics of Parasites is a major interest, with several laboratories in the Malaria Group focussing on defined antigens in malaria parasites. These antigens present potential for new vaccines, and complement a long-standing interest in protozoan genetics. Trypanosome molecular biology aims to understand cell cycle control and differentiation with a view to novel drug development. The molecular biology of helminth parasites (worms) is also under study in IIIR.
Host-Pathogen Population Biology is an important stream of activity, which bridges from conventional immunology and pathogen research into systems-level quantitative biology. This field is rapidly growing, in the wake of demonstrating the interaction between, for example, vaccination and the emergence of pathogen virulence.
Each of these areas has a long history of Research in Ashworth Laboratories.
These four strands are closely interlinked within IIIR and also have firm connections with other research specialities on the Edinburgh scene.
This article was published on Mar 25, 2010