Dr. S.A. Knott
Location: 135, Ashworth Labs
Ph.D., University of Edinburgh, 1990 (at the AFRC Institute of Animal Physiology and Genetics Research).
Population and Quantitative Genetics
QTL analysis (MSc in Quantitative Genetics and Genome Analysis)
My research focuses on the use of molecular markers to determine the loci responsible for variation in quantitative traits (quantitative trait loci or QTL) with the ultimate purpose being to understand the nature of genetic variation underlying complex traits. I am particularly interested in the development and application of statistical methods to detect and characterise QTL that are segregating in outbred populations (of plants, animals or humans).
Link to QTL analysis software package QTL Express
Nagamine, Y, Knott, SA, Visscher, PM & Haley, CS. (2002). Simple deterministic identity-by-descent coefficients and estimation of QTL allelic effects in full and half sibs. Genetical Research 80, 237-243.
Seaton, G, Haley, CS, Knott, SA, Kearsey, M, Visscher, PM. (2002). QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18, 339-340.
Knott, SA, Nystrom, PE, Andersson-Eklund, L, Stern, S, Marklund, L, Andersson, L, Haley, CS. (2002). Approaches to interval mapping of QTL in a multigeneration pedigree: the example of porcine chromosome 4. Animal Genetics 33, 26-32.
Knott, SA, Haley, CS. (2000). Multitrait least squares for quantitative trait loci detection. Genetics 156, 899-911.
Knott, S.A. and Haley, C.S. (1998). Simple multiple-marker sib-pair analysis for mapping quantitative trait loci. Heredity 81: 48-54
Knott, S.A., Marklund, L., Haley, C.S., Andersson, K., Davies, W., Ellegren, H., Fredholm, M., Hansson, I., Hoyheim, B.,Lundstrom, K., Moller, M., and Andersson, L. (1998). Multiple marker mapping of quantitative trait loci in an outbred cross between wild boar and Large White pigs. Genetics 149: 1069-1080.
Knott, S.A., Neale, D.B., Sewell, M.M. and Haley, C.S. (1997). Multiple marker mapping of quantitative trait loci in an outbred pedigree of loblolly pine. Theor Appl Genet 94 : 810-820.
This article was published on May 15, 2012