Professor Ian Jackson (PhD FRSE)
Programme Leader/ Professorial Fellow
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
Ian Jackson has a First Class degree in Biochemistry from the University of Oxford. He went on to do a PhD with Bob Williamson at St. Mary's Hospital in London, at the very beginning of DNA cloning studies on humans. In 1981 he joined Don Brown's laboratory at the Carnegie Institution in Baltimore where he studies TF3A, the first vertebrate transcription factor to be identified. He subsequently joined the MRC Mammalian Development Unit at UCL, under the Directorship of Anne McLaren. In 1986 Ian moved to the MRC Human Genetics Unit as a Lister Fellow. He became an MRC Senior Scientist in 1991 and Head of Disease Mechanisms in 2009. He was elected a Fellow of the Royal Society of Edinburgh in 2008. Among other current responsibilities he is a Board member of the National Centre for 3Rs.
Qualifications
BA Biochemistry, 1st class, University of Oxford
PhD, University of London "Isolation and Characterisation of Human Globin and Interferon genes"
Research summary
Mouse models of human and animal disease
Current research interests
We study mice with genetic mutations in order to understand how genes control normal human development and disease. Mice have almost the same set of genes as humans, and malfunction or mutation of these genes usually has very similar consequences. We study how genetic mutations lead to eye disease, in two ways. Firstly we examine mice in which random mutations have been created, in order to identify mutation that result in eye disease. Secondly, we look at mice in which particular genes have been knocked out as part of a project that is systematically mutating every gene one by one. We also study how genes control melanocytes, which are the cells in the body producing pigment in skin and hair. These cells have a very interesting embryonic histroy, and genes affect how these cells develop, proliferate and become located at the correct places in the skin and hair follicle. Research Groups Denis Headon Albert Tenesa Kim Summers Pleasantine Mill Liz Patton-
Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model
(13 pages)
In:
Nature Communications, vol. 7
DOI: https://doi.org/10.1038/ncomms10288
Research output: Contribution to Journal › Article (Published) -
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice
In:
Developmental Cell, vol. 47, pp. 509-523.e5
DOI: https://doi.org/10.1016/j.devcel.2018.10.027
Research output: Contribution to Journal › Article (Published) -
Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability
(10 pages)
In:
Nature Communications, vol. 9
DOI: https://doi.org/10.1038/s41467-018-07691-z
Research output: Contribution to Journal › Article (Published) -
Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-019-57398-4
Research output: Contribution to Journal › Article (Published) -
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification
In:
PLoS Genetics
DOI: https://doi.org/10.1371/journal.pgen.1008583
Research output: Contribution to Journal › Article (E-pub ahead of print)