Dr Stephen Wallace

Lecturer in Biotechnology

Background

2016        Postdoctoral Research Fellow, University of Cambridge

2015        Visiting Postdoctoral Research Assistant, Massachusetts Institute of Technology

2014        Postdoctoral Research Fellow, Harvard University

2012        Postdoctoral Research Fellow, MRC Laboratory of Molecular Biology, Cambridge

Qualifications

2012        DPhil. Organic Chemistry, University of Oxford

2008        MChem. Medicinal and Biological Chemistry with Industrial Experience, University of Edinburgh

Research summary

biotechnology, synthetic biology, whole-cell biocatalysis, bioconjugation chemistry, synthetic organic chemistry

Designer Micelles Accelerate Flux Through Engineered Metabolism and Support Biocompatible Chemistry. S. Wallace, E. P. Balskus, Angew. Chem. Int. Ed. 2016, 55, 6023–6027 - link

Interfacing Microbial Styrene Production with a Biocompatible Cyclopropanation Reaction. S. Wallace, E. P. Balskus, Angew. Chem. Int. Ed. 2015, 54, 7106–7109 - link

Using Non-Enzymatic Chemistry to Influence Microbial Metabolism. S. Wallace, E. E. Shultz, E. P. Balskus, Curr. Opin. Chem. Biol. 2015, 25, 71–79 - link

Opportunities for Merging Chemical and Biological Synthesis. S. Wallace, E. P. Balskus, Curr. Opin. Biotechnol. 2014, 30, 1–8 - link

Strain-Promoted Sydnone Bicyclo-[6.1.0]-nonyne Cycloaddition. S. Wallace, J.  W. Chin, Chem. Sci. 2014, 5, 1742–1744 - link

Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. A. Darko, S. Wallace, O. Dmitrenko, M. M. Machovina, R. A. Mehl, J. W. Chin, J. M. Fox, Chem. Sci. 2014, 5, 3770–3776 - link

Optimized Orthogonal Translation of Unnatural Amino Acids Enables Spontaneous Protein Double-Labeling and FRET. K. Wang, A. Sachdeva, D. J. Cox, N. W. Wilf, S. Wallace, R. A. Mehl, J. W. Chin, Nat. Chem. 2014, 6, 393–403 - link

A Cascade Strategy Enables a Total Synthesis of (–)-Gephyrotoxin. S. Chu, S. Wallace, M. D. Smith, Angew. Chem. Int. Ed. 2014, 53, 13826–13829 - link

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in vitro and in Live Mammalian Cells. K. Lang, L. Davis, S. Wallace, M. Mahesh, D. J. Cox, M. L. Blackman, J. M. Fox, J. W. Chin, J. Am. Chem. Soc. 2012, 134, 10317–10320 - link

Rapid Synthesis and Zebrafish Evaluation of a Phenanthridine-Based Small Molecule Library. L. R. Donaldson, S. Wallace, D. Haigh, E. E. Paton, A. N. Hulme, Org. Biomol. Chem. 2011, 9, 2233–2239 - link