Division of Infection and Pathway Medicine

Sloan Group publication in Journal of Virology

The Sloan group has published an article "RNA-associated Early-stage Anti-viral Factor (REAF) is a major component of LV2 restriction." in the Journal of Virology.

Working in collaboration with Prof Aine McKnight of Barts and The London School of Medicine, this work shows how HIV-1 and HIV-2 can be potently inhibited by the cellular restriction factor REAF/Lv2. It is hoped by that understanding the molecular basis of HIV restriction by REAF/Lv2  it may be possible to explain variations in susceptibility to HIV infection and progression, or to identify new therapeutic targets against the virus.

Full article

Professor Aine McKnight