Social network helps bug spread

Findings about how bacteria co-operate to cause infection may help spot diseases that might jump from animals to people.

Bugs that can co-operate best with each other are most likely to be able to jump to new species, including humans, a new study shows.

Bacteria interact by releasing molecules to help them adapt to their environment - for example, when killing competing infections in their victim.

They co-ordinate these actions by releasing tiny amounts of chemicals as signals.

Spread to new species

Co-operation is important for the spread of bacteria to new species.

Dr Luke McNally

School of Biological Sciences

Bacteria that can co-operate to create an environment in which they can thrive are potentially able to infect lots of different species, including humans.

Discovering why some diseases are better equipped to infect more species than others - and therefore could affect humans - could be valuable in predicting and managing health threats.

Most new human infections arise from diseases that transmit from animals to humans.

Many of these cause serious infections and are difficult to control, such as anthrax and the superbug MRSA.

Mass gene study

Research led by the University used a combination of mathematical models and scientific analysis of genetic code in almost 200 types of bacteria.

They found that those bugs that carry lots of genes that help them to co-operate are best equipped to adapt to various environments.

The study, published in the journal Nature Communications, was carried out in collaboration with the University of Glasgow. It was supported by the Wellcome Trust, the Engineering and Physical Sciences Research Council and the Royal Society.

Humans have been able to colonise almost all of their planet by collectively modifying the environment to suit themselves. Our study shows bugs try to do the same.

Dr Luke McNally

School of Biological Sciences

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