Grzegorz Kudla Research Group
RNA Synthetic Biology
Research in a Nutshell
The Kudla lab combines synthetic biology, next-generation sequencing, and computational modelling to study the relationships between RNA sequence, structure, expression, and function. The group focuses on the study of codon usage bias, RNA folding, and RNA interactions. We believe that a detailed understanding of the sequence-function relationship for selected model transcripts will uncover principles applicable to many RNAs.
People |
|
Professor Grzegorz Kudla | Group Leader |
Pragya Mittal |
Research Fellow |
Fernando Bellido Molías |
Research Fellow |
Marcin Plech | Research Fellow (with Joe Marsh) |
Hasan Çubuk |
PhD student (with Joe Marsh) |
Jian You Lau | Research Assistant |
Alex McDonnell | PhD student |
Laura Cano Aroca | PhD student |
Mohd Ahmad | PhD student |
Nabid Bhuiyan | PhD student |
Serafina Soehianto | MRes student |
Contact
Publications
- Gabryelska et al (2022) Global mapping of RNA homodimers in living cells. Genome Research 32 (5) 956-967
- Zhang et al (2021) In vivo structure and dynamics of the SARS-CoV-2 RNA genome. Nature communications 12 (1)
- Mordstein et al (2020) Codon usage and splicing jointly influence mRNA localization. Cell systems 10 (4) 351-362
- Mittal et al. (2018) Codon usage influences fitness through RNA toxicity. Proceedings of the National Academy of Sciences 115 (34) 8639-8644
- Ziv et al (2018) COMRADES determines in vivo RNA structures and interactions. Nature methods 15 (10) 785-788
Full publication list can be found on Research Explorer: Grzegorz Kudla — University of Edinburgh Research Explorer
Collaborations
- Professor Laurence Hurst, University of Bath
- Dr Michael Liss, Thermo Fisher Scientific
- Professor Eric Miska, University of Cambridge
Partners and Funders
- MRC
- Wellcome Trust
Scientific Themes
gene regulation, evolution, RNA, codon usage, synthetic biology