We are interested in regulation of protein synthesis in neuropsychiatric disorders.
A large proportion of the cell’s energy resources are devoted to protein synthesis, which is also referred to as mRNA translation. Proteins catalyse most of the reactions in the cell on which life depends. Translational control is defined as a change in protein production per mRNA per unit of time, and it is a powerful means to alter protein abundance.
My lab is particularly interested in understanding the molecular and signalling mechanisms of translational control in the brain and how they control complex brain functions and behaviours, such as learning, memory, social interactions, anxiety and fear.
Using biochemical, electrophysiological and behavioural analysis in rodents and in vitro, we wish to examine translational control as a key tenet in the pathophysiology of neuropsychiatric/neurodevelopmental disorders such as ASD, Fragile X Syndrome (FXS) and Intellectual Disability (ID).