Centre for Integrative Physiology

Dr Christos Gkogkas

We are interested in regulation of protein synthesis in neuropsychiatric disorders.

Christos Gkogkas

Chancellor's Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Personal profile

  • 2013-present: Chancellor’s Fellow, Centre for Integrative Physiology and The Patrick Wild Centre, University of Edinburgh, UK
  • 2009-2013: Post-doctoral Fellow, Biochemistry Department, Laboratory of Professor Nahum Sonenberg, McGill University, Canada
  • 2005-2009: PhD, Centre For Neuroscience Research, Laboratory of Dr. Paul Skehel, University of Edinburgh, UK
  • 1999-2004: BSc in Biology, Department of Biology, University of Athens, Greece

Research

A large proportion of the cell’s energy resources are devoted to protein synthesis, which is also referred to as mRNA translation. Proteins catalyse most of the reactions in the cell on which life depends. Translational control is defined as a change in protein production per mRNA per unit of time, and it is a powerful means to alter protein abundance.

My lab is particularly interested in understanding the molecular and signalling mechanisms of translational control in the brain and how they control complex brain functions and behaviours, such as learning, memory, social interactions, anxiety and fear.

Using biochemical, electrophysiological and behavioural analysis in rodents and in vitro, we wish to examine translational control as a key tenet in the pathophysiology of neuropsychiatric/neurodevelopmental disorders such as ASD, Fragile X Syndrome (FXS) and Intellectual Disability (ID).

Team members

  • Tine Pooters (Postdoctoral Fellow)
  • Sonal Kedia (Postdoctoral Fellow)
  • Nicolette McGill (Technician)
  • Stella Kouloulia (PhD student)
  • Konstanze Simbriger (PhD student)
  • Ines Da Silva Amorim (Postdoctoral Fellow)

External collaborations

  • Raymond Kelleher (Harvard Medical School and Massachusetts General Hospital, USA)
  • Clive Bramham (University of Bergen, Norway)
  • Jeffrey Mogil (McGill university, Canada)
  • Nahum Sonenberg (McGill university, Canada)

Publications

Dr Gkogkas's full publication list (pubmed)