Centre for Integrative Physiology

Publication highlights

Our extensive publication list for 2015

Publications for 2015, alphabetically by first author.

Please note that not all journals provide open access.

Adutwum-Ofosu KK, Magnani D, Theil T, Price DJ, Fotaki V. (2015) The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain. Brain Struct Funct. Oct 12. [Epub ahead of print]

Adutwum-Ofosu et al.

Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. (2015) Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. Hypertension. 66(3):667-73.

Aguilar-Valles et al.

Anderson RA, Mitchell RT, Kelsey TW, Spears N, Telfer EE, Wallace WH (2015) Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol.; 3(7):556-67.

Anderson et al.

Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C (2015) G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. J Cell Biol.;209(1):73-84

Aulas et al.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ. (2015) Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice. J Neurosci. 35(45):15073-81.

Barnes et al.

Baxter PS, Bell KF, Hasel P, Kaindl AM, Fricker M, Thomson D, Cregan SP, Gillingwater TH, Hardingham GE. (2015) Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nat Commun. 6:6761.

Baxter et al.

Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE. (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nat Commun. 6:7066.

Bell et al.

Brown R, Hynes-Allen A, Swan AJ, Dissanayake KN, Gillingwater TH, Ribchester RR. (2015) Activity-dependent degeneration of axotomized neuromuscular synapses in Wld S mice. Neuroscience;290:300-20.

Brown et al.

Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nat Neurosci. (6):855-62.

Cao et al.

Chadwick A, van Rossum MC, Nolan MF. (2015) Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping. Elife. 4:e03542

Chadwick et al.

Chamberlain LH, Shipston MJ. (2015) The physiology of protein S-acylation. Physiol Rev. 95(2):341-76. Review.

Chamberlain et al.

Chan WK, Howe K, Clegg JM, Guimond SE, Price DJ, Turnbull JE, Pratt T. (2015) 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS One. 10(6):e0130147

Chan et al.

Clarkson YL, Perkins EM, Cairncross CJ, Lyndon AR, Skehel PA, Jackson M. (2015) β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations. Hum Mol Genet.; 23(14):3875-82

Clarkson et al.

Clegg JM, Li Z, Molinek M, Caballero IM, Manuel MN, Price DJ. (2015) Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons. Neural Dev.;10(1):26.

Clegg et al.

Combes AN, Davies JA, Little MH. (2015) Cell-cell interactions driving kidney morphogenesis. Curr Top Dev Biol.;112:467-508.

Combes et al.

Davies JA. (2015) Synthetic Biology: Rational Pathway Design for Regenerative Medicine. Gerontology. 2015 Oct 17. [Epub ahead of print]

Davies JA.

Davies, J. R., Humby, T., Dwyer, D. M., Garfield, A. S., Furby, H., Wilkinson, L. S., Wells, T., Isles, A. (2015) Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader–Willi syndrome Eur J Neurosci. 42(4):2105-13.

Davies et al.

Dodson PD, Larvin JT, Duffell JM, Garas FN, Doig NM, Kessaris N, Duguid IC, Bogacz R, Butt SJ, Magill PJ. (2015) Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus. Neuron. 86(2):501-13.

Dodson et al.

Duncan PJ, Sengül S, Tabak J, Ruth P, Bertram R, Shipston MJ. (2015) Large conductance Ca 2+ -activated K+(BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs. J Physiol. 593(5):1197-211.

Duncan et al.

Eltawil, Noha M, Howie, Sarah E M, Simpson, A Hamish R W, Amin, Anish K, Hall, Andrew C (2015) The use of hyperosmotic saline for chondroprotection: implications for orthopaedic surgery and cartilage repair. Osteoarthritis Cartilage. 23(3):469-77

Eltawil et al.

Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. (2015) A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. (6):863-71.

Garfield et al.

Georgas KM, Armstrong J, Keast JR, Larkins CE, McHugh KM, Southard-Smith EM, Cohn MJ, Batourina E, Dan H, Schneider K, Buehler DP, Wiese CB, Brennan J, Davies JA, Harding SD, Baldock RA, Little MH, Vezina CM, Mendelsohn C. (2015) An illustrated anatomical ontology of the developing mouse lower urogenital tract. Development 142(10):1893-908.

Georgas et al.

Gillingwater, T. H., Murray, L. M. (2015) How far away is spinal muscular atrophy gene therapy? Expert Rev Neurother.15(9):965-8.

Gillingwater  and  Murray

Groen, E.J. & Gillingwater, T.H. (2015) UBA1: at the crossroads of ubiquitin homeostasis and neurodegeneration. Trends in Molecular Medicine 21: 622-632.

Groen et al.

Haddad-Tovolli, R., Paul, F. A., Zhang, Y., Zhou, X., Theil, T., Puelles, L., Blaess, S., Alvarez-Bolado, G. (2015) Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus. Front Neuroanat. 9:58.

Haddad-Tovolli et al.

Hao K, Kong FP, Gao YQ, Tang JW, Chen J, Evans AM, Lightman SL, Chen XQ, Du JZ. (2015) Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia. Diabetes. 64(3):785-95.

Hao et al.

Harris AP, Lennen RJ, Marshall I, Jansen MA, Pernet CR, Brydges NM, Duguid IC, Holmes MC. (2015) Imaging learned fear circuitry in awake mice using fMRI. Eur J Neurosci.May 5.  [Epub ahead of print]

Harris et al.

Henstridge CM, Jackson RJ, Kim JM, Herrmann AG, Wright AK, Harris SE, Bastin ME, Starr JM, Wardlaw J, Gillingwater TH, Smith C, McKenzie CA, Cox SR, Deary IJ, Spires-Jones TL. (2015) Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathol Commun. 3(1):53.

Henstridge et al.

Heye AK, Thrippleton MJ, Chappell FM, Valdés Hernández MD, Armitage PA, Makin SD, Maniega SM, Sakka E, Flatman PW, Dennis MS, Wardlaw JM. (2015)  Blood pressure and sodium: association with MRI markers in cerebral small vessel disease. J Cereb Blood Flow Metab. Apr 22. [Epub ahead of print]

Heye et al.

Howie J, Reilly L, Fraser NJ, Vlachaki Walker JM, Wypijewski KJ, Ashford ML, Calaghan SC, McClafferty H, Tian L, Shipston MJ, Boguslavskyi A, Shattock MJ, Fuller W. (2015) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proc Natl Acad Sci U S A. 111(49):17534-9.

Howie et al.

Keighren MA, Flockhart J, Hodson BA, Shen GY, Birtley JR, Notarnicola-Harwood A, West JD. (2015) Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers. Transgenic Res.;24(4):665-91.

Keighren et al.

Leng G, Ludwig M. (2015) Intranasal Oxytocin: Myths and Delusions. Biol Psychiatry. 2015 May 11 [Epub ahead of print]

Leng and Ludwig

Leng G., Pineda Reyes R., Sabatier N., Ludwig M. (2015) The posterior pituitary: from Geoffrey Harris to our present understanding. J Endocrinol. 226(2):T173-85

Leng et al.

Leng, G., Russell, J. A. (2015) The peptide oxytocin antagonist F-792, when given systemically, does not act centrally in lactating rats. J Neuroendocrinol. Oct 24. [Epub ahead of print]

Leng et al.

Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J. (2015) Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. J Biol Chem. 290(6):3377-89

Lin  et al.

Lindström NO, Lawrence ML, Burn SF, Johansson JA, Bakker ER, Ridgway RA, Chang CH, Karolak MJ, Oxburgh L, Headon DJ, Sansom OJ, Smits R, Davies JA, Hohenstein P. (2015) Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron. Elife. Feb 3;4.

Lindström et al.

Ludwig M., Stern J. (2015) Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin. Philos Trans R Soc Lond B Biol Sci.; 370(1672)

Ludwig and Stern

Magnani D, Morlé L, Hasenpusch-Theil K, Paschaki M, Jacobi M, Schurmans S, Durand B, Theil T. (2015) The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 24(9):2578-93.

Magnani et al.

Maity S, Rah S, Sonenberg N, Gkogkas CG, Nguyen PV. (2015) Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learn Mem. 22(10):499-508.

Maity et al.

Manuel, M. N., Mi, D., Mason, J. O., Price, D. J. (2015) Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front. Cell. Neurosci., doi: 10.3389/fncel.2015.00070

Manuel et al.

Martin-Navarro, C. M., Lopez-Arencibia, A., Sifaoui, I., Reyes-Battle, M., Valladares, B., Martinez-Carretero, E., Pinero, J. E.,Maciver, S. K., Lorenzo-Morales, J. (2015) Statins and voriconazole induce Programmed Cell Death in Acanthamoeba. Antimicrob Agents Chemother.; 59(5):2817-24.

Martin-Navarro et al.

Morton A, Marland JR, Cousin MA. (2015) Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis. J Neurochem.;134(3):405-15

Morton et al.

Nicholson-Fish, J. C., Cousin, M. A., Smillie, K. J. (2015) Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals. Neurochem Res. Jul 22. [Epub ahead of print]

Nicholson-Fish et al.

Nicholson-Fish J.C., Kokotos A.C., Gillingwater T.H., Smillie K.J. & Cousin M.A. (2015) VAMP4 is an essential cargo molecule for activity-dependent bulk endocytosis. Neuron In Press.

Nicholson-Fish et al.

Ogunbayo OA, Zhu Y, Shen B, Agbani E, Li J, Ma J, Zhu MX, Evans AM. (2015) Organelle-specific subunit interactions of the vertebrate two-pore channel family. J Biol Chem. 290(2):1086-95

Ogunbayo et al.

Parolin Schnekenberg R, Perkins EM, Miller JW, Davies WI, D'Adamo MC, Pessia M, Fawcett KA, Sims D, Gillard E, Hudspith K, Skehel P, Williams J, O'Regan M, Jayawant S, Jefferson R, Hughes S, Lustenberger A, Ragoussis J, Jackson M, Tucker SJ, Németh AH. (2015) De novo point mutations in patients diagnosed with ataxic cerebral palsy. Brain.; 138(Pt 7):1817-32.

Parolin Schnekenberg et al.

Paterson SI, Amin AK, Hall AC. (2015) Airflow accelerates bovine and human articular cartilage drying and chondrocyte death. Osteoarthritis Cartilage. 23(2):257-65.

Paterson et al.

Powis, R.A. & Gillingwater, T.H. (2015) Selective loss of alpha motor neurons with sparing of gamma motor neurons and spinal cord cholinergic neurons in a mouse model of spinal muscular atrophy. Journal of Anatomy In Press.

Powis et al.

Ramsden HL, Sürmeli G, McDonagh SG, Nolan MF. (2015) Laminar and Dorsoventral Molecular Organization of the Medial Entorhinal Cortex Revealed by Large-scale Anatomical Analysis of Gene Expression. PLoS Comput Biol. 11(1):e1004032

Ramsden et al.

Ribchester RR. (2015) Some reminiscences on studies of age-dependent and activity-dependent degeneration of sensory and motor endings in mammalian skeletal muscle. J Anat.;227(2):231-6.


Sanhueza M, Chai A, Smith C, McCray BA, Simpson TI, Taylor JP, Pennetta G.(2015) Network Analyses Reveal Novel Aspects of ALS Pathogenesis. PLoS Genet. 11(3):e1005107.

Sanhueza et al.

Schiemann J, Puggioni P, Dacre J, Pelko M, Domanski A, van Rossum MC, Duguid I. (2015) Cellular Mechanisms Underlying Behavioral State-Dependent Bidirectional Modulation of Motor Cortex Output. Cell Rep. 11(8):1319-30.

Schiemann et al.

Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi-Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., Moore, L. G. (2015) Hypoxia, AMPK activation and uterine artery vasoreactivity. J Physiol. Jun 25.[Epub ahead of print]

Skeffington et al.

Solanka L, van Rossum MC, Nolan MF.(2015) Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks. Elife. 2015 Jul 6;4.

Solanka et al.

Somers E, Lees RD, Hoban K, Sleigh JN, Zhou H, Muntoni F, Talbot K, Gillingwater TH, Parson SH. (2015) Vascular defects and spinal cord hypoxia in spinal muscular atrophy. Ann Neurol. Oct 27.  [Epub ahead of print]

Somers et al.

Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P., Buneman, O. P., Davenport, A. P., McGrath, J. C., Peters, J. A., Spedding, M., Catterall, W. A., Fabbro, D., Davies, J. A. (2015)  The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res. Oct 12. [Epub ahead of print]

Southan et al.

Styczynska-Soczka K, Jarman AP. (2015) The Drosophila homologue of Rootletin is required for mechanosensory function and ciliary rootlet formation in chordotonal sensory neurons.Cilia 2015, 4:9.

Styczynska-Soczka et al.

Suslak TJ, Watson S, Thompson KJ, Shenton FC, Bewick GS, Armstrong JD, Jarman AP. (2015) Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons. PLoS One. 2015 Jul 17;10(7):e0130969.

Suslak et al.

Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR. (2015) Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1. J Neurosci. 35(6):2492-507

Zhang et al.