Centre for Integrative Physiology

Hope for dementia treatment

May 2017: In a recent study, Prof Giles Hardingham and colleagues uncovered mechanisms involved in the protection of nerve cells.

Fluorescent cells

It has been known for over 30 years that when neurons are active, certain genes are turned on. These genes are important for neurons to develop and mature, as well as for learning, memory, and even survival of neurons in adults.

However, in the human brain the number of neurons is at least matched by the number of other cells - called glia - which play crucial roles in the survival and support of neurons.

Until now, how and if neurons control gene expression in glia was completely unknown.

Professor Hardingham’s group showed that neurons do in fact control the expression of hundreds of genes in particular glial cells called astrocytes.

They found that neurons controlled the expression of astrocytic genes that are essential for the neurons themselves to pass messages to one another. Additionally, it was discovered that when neurons were active they turned on astrocytic genes leading to increased antioxidant and nutritional support of neurons.

The group went on to find that such neuro-protective genes were turned down in astrocytes in neurodegenerative disease and ageing. These results shine a new light onto how the ability of glia to protect neurons may become impaired in dementia, giving hope for a potential new route for treatment.

Now we have uncovered the signal pathways that control the neuro-protective genes in astrocytes, our next step is to try to artificially manipulate these pathways to boost the capacity of astrocytes to protect neurons, which may validate these pathways as potential therapeutic targets.

Prof Giles Hardingham

 

Related links

Nature Communications

Prof Giles Hardingham's research profile