Sandrine Prost studies multispectral imaging assessment of multiple markers on biopsy samples.
Sandrine Prost graduated from the University Pierre and Marie Curie, (Paris VI, France) with a PhD in molecular pharmacology studying mechanisms of resistance to antitumor agents that target topoisomerases. She then joined the University of Edinburgh as a European Commission Marie Curie Research Fellow to work on the role of P53 in apoptosis and DNA repair.
Her interests developed from carcinogenesis and the role of tumour suppressor genes in cell responses to injury, in particular the effects of DNA damage and the cell cycle responses to a wider theme of cell injury. She became senior lecturer in 2001 in the Liver Injury and Repair Group of the University Department of Pathology.
Current translational research aims to develop new diagnostic approaches on clinical biopsy material, relevant to prognosis and personalised treatment in immune and inflammatory diseases, including transplantation. The approach includes the use of multispectral imaging technology to gain new insights into rare and hybrid cell populations within diseased tissue, recently involving in situ phenotyping of macrophages in biopsies.
I am interested in the cellular reactions to injury and their role in determining pathogenesis and disease outcome. Our current translational research aims to identify within the diseased tissue new biomarker combinations to improve the recognition and management of inflammatory renal and hepatic disease. We have been using RNAscope (ACDbio) to sensitively detect low level hepatitis viral RNA in situ within tissue samples and multispectral imaging (Nuance Perkin Elmer) in the per-cell evaluation of multiple (5+) markers on clinical biopsy samples. Recent work includes a detailed comparative in situ phenotyping study of macrophages in clinical inflammatory and allo-immune conditions affecting the liver and kidney.
Sandrine Prost is a senior lecturer who trained in Paris and joined the Pathology department in 1995.
October 2000 Invited instructor for the EMBO Course, "From mice to cells" EMBL Heidelberg
July 2003 Official Monitoring the Gordon’s Research Conferences 2Molecular & Genetic Basis of Cell Proliferation" Colby-Sawyer College, Boston.
I supervised many research students at both undergraduate and postgraduate levels. I apologise in advance to those not mentioned by name.
Undergraduates: I supervised 9 BSc (Hons) students in Experimental Pathology who all successfully graduated with at least a 2:1 ; including Sian Stephens (1997-98), Charlotte Warren-Gash (1999-2000), Marion Campbell, Yuen-Sum Samantha Chan (2000-01), Karl Symonds (2001-02), Chris Kane (2003-04) and Matt Parker (2004-05)
Postgraduates: 4 students enrolled on the Wellcome 4 Years PhD (Cellular and molecular basis of disease) for their 1st year miniproject including Aziz Aboobaker (1998) and Clett Erridge (1999)
7 Masters by Research in Life Sciences for their Cancer biology project, including Manish Mittal and Zhenjie Xu, and finally 10 PhD students: 3 as main supervisor; 7 as 2nd supervisor
Sharon Sheahan (main supervisor) 1997-2001 went on to do a Postdoc in Oxford and is now Commercialisation Case Manager at Teagasc & University College Cork
Louise Treanor (main supervisor) 2002-2006 went on to do a Postdoc St Jude Children's research hospital now Principal Scientist at Novartis Institute for BioMedical Research (NIBR) Cambridge, Massachusetts
Stephen Boyce 2002-2006 (main supervisor) Surgeon, back to surgery
And as second supervisor 7 students including Kerry B, Ben Tura, Nicola Martin and Chris McCullough.
Finally, Pin Lu and Nick Wheelhouse who joined me as postdocs, and really competent technicians Clare Taylor, Shoena Gillies, Dominic Rannie, Helen Caldwell and Ria Kishen.
Sandrine Prost is project manager for the undergraduate Laboratory Medicine curriculum review and manager of the Laboratory Medicine Mobile Learning project.