MRC Centre for Inflammation Research
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Dr Gwo-Tzer Ho

Gwo-Tzer Ho aims to understand how the deregulation of the key intestinal epithelial protective mechanisms which regulate mucosal homeostasis underpin the development of the inflammatory bowel diseases (Ulcerative colitis and Crohn's disease).

Dr Gwo-Tzer Ho

MRC Clinician Scientist and Honorary Consultant Gastroenterologist

  • MRC Centre for Inflammation Research
  • Research Theme: Tissue Remodelling and Regeneration

Contact details

Background

Gwo-Tzer Ho completed his undergraduate- and postgraduate medical training (MBChB 1997 and MRCP 2000) in Glasgow, and his PhD in Edinburgh University under Professor Jack Satsangi (2000-2003). He specialised in gastroenterology in Edinburgh (2003-2008) and has a special interest in the molecular mechanisms in the pathogenesis of IBD. Gwo-Tzer currently holds an MRC Clinician Scientist Fellowship award and is an honorary consultant gastroenterologist at the Western General Hospital. Gwo-Tzer trained under Professor Balfour Sartor in University of North Carolina, Chapel Hill, USA (2009-2010) studying epithelial-microbial interactions in IBD and moved to the MRC Centre for Inflammation Research in 2011 to establish his current program of in vivo work ,whilst maintaining close collaborations with the Gastrointestinal Unit led by Professor Jack Satsangi at the Centre for Genomic and Experimental Medicine (CGEM). 

Research Overview

Ulcerative colitis and Crohn's disease are common chronic relapsing inflammatory bowel diseases (IBD) affecting 0.5% of the population in Northern Europe and USA. The global  incidence and prevalence of IBD is set to rise dramatically with the Westernisation of the developing world. Our current understanding of disease pathogenesis remains incomplete and there is a major unmet clinical need for new treatments for these conditions associated with considerable morbidity. My program of work aims to understand the molecular mechanisms by which intestinal epithelial dysfunction influence mucosal homeostasis in IBD. A major focus is how distinct inflammatory signals originating from the dysfunctional gut epithelium drives the abnormal inflammation in IBD. We are interested in how mucosal protective processes, in particular epithelial detoxification, autophagy and mitochondrial function, become deregulated leading to the genesis of these inflammatory signals. Our aim is to use this as the basis for the development of new therapies in IBD. Our scientific work is closely integrated to the clinic, where I am actively involved in tertiary IBD patient care (Western General Hospital) and research (Scottish NIHR member and British Society of Gastroenterology Academic committee 2011-present). In recent studies, we have established studies focused on patients as a key link to current findings from our in vivo colitis models (co-PI in Chief Scientist Office-funded IBD biobank 2010-2011). 

Honours and Awards

  • 2016  Fellow of Royal College of Physicians (Edinburgh)
  • 2009  Medical Research Council Clinician Scientist Fellowship
  • 2008  United European Gastroenterology Rising Star Award
  • 2007  British Society of Gastroenterology CORE Research Prize
  • 2006  European Crohn’s and Colitis Organization (ECCO) Researcher Award for UK
  • 2004-6  American Gastroenterology Association Abstracts of Distinction (3 awards)

Collaborators

  • Professor Balfour Sartor: University of North Carolina, Chapel Hill, USA
  • Dr Takahiko Shimizu: Chiba University, Japan

Sources of Funding

More information on funding at Gwo-Tzer Ho's Research Explorer profile.