Together with a team of developers at the Human Genetics Unit in Edinburgh we run the database for the GenitoUrinary Development Molecular Anatomy Project (GUDMAP). [scald=878:sdl_editor_representation {"caption":""}] Personal profile 2005- present: Senior editor, GUDMAP SBMS, University of Edinburgh 2003-2005: Associate Scientist, Genentech Inc, San Francisco, USA 2002-2003: Independent Postdoc Fellow, Institute for Stem Cell Research, University of Edinburgh 1998-2002: Postdoctoral Fellow, Dept Molecular and Cellular Biology, Harvard University 1993-1998: PhD student, Institute for Stem Cell Research, University of Edinburgh 1991-1993: Research Assistant, Ludwig Institute for Cancer Research, University College London 1988-1991: BSc Biochemistry, University of Manchester Research This is an international consortium working to generate gene expression data and transgenic mice. GUDMAP includes data from large-scale in situ hybridisation screens (wholemount and section) and microarray gene expression data of microdissected, laser-captured and FACS-sorted components of the developing mouse genitourinary (GU) system. These expression data are annotated using a high-resolution anatomy ontology specific to the developing murine GU system. GUDMAP data are freely accessible at www.gudmap.org via easy-to-use interfaces. This curated, high-resolution dataset serves as a powerful resource for biologists, clinicians and bioinformaticians interested in the developing urogenital system. Funding National Institute for Health, USA Team members Professor Jamie Davies (PI) Dr Jane Armstrong Dr Mathieu Unbekandt Ms Sue Lloyd-MacGilp Collaborations Prof Richard Baldock, Human Genetics Unit, Edinburgh Prof Andrew McMahon, Harvard University, USA Prof Melissa Little, University of Queensland, Australia Prof Bruce Aronow, Cincinnati Children's Hospital Medical Centre, USA Selected publications Harding, SD., Armit, C., Armstrong J., Brennan J et al. (2011) The GUDMAP database - an online resource for genitourinary research. Development. Jul; 138(13):2845-2853. Little, M.H., Brennan, J et al (2007) A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expression Patterns, Jun;7(6):680-99 Brennan, J., Norris, D.P. and Robertson, E.J. (2002) Nodal activity in the node governs left-right asymmetry in the mouse. Genes and Development, 16(18), 2339-44 Brennan, J., Lu, C.C., Norris, D.P., Rodriguez, T.A., Beddington, R.S.P. and Robertson, E.J. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature, 411, 965-969 Mitchell, K.J., Pinson, K.I., Kelly, O.G., Brennan, J., Zupicich, J., Scherz, P., Leighton, P.A., Goodrich, L.V., Lu, X., Avery, B.J., Tate, P., Dill, K., Pangilinan, E., Wakenight, P., Tessier-Lavigne, M & Skarnes, W.C. (2001) Functional analysis of secreted and transmembrane proteins critical to mouse development. Nature Genetics 28, 241-249 Jane Brennan publication list (pdf) This article was published on 2022-10-17
