We aim to characterise changes in brain structure in old age and investigate relationships between brain ageing and cognitive decline using a unique and extremely well-characterised model of healthy ageing (LBC 1936 cohort). Dr Declan King Postdoctoral Associate 1 George Square Edinburgh EH8 9JZ Contact details Work: +44 (0) 131 651 1884 Email: Declan.king@ed.ac.uk Web: Spires-Jones Research Group Personal profile 2018 - Present: Postdoctoral Associate, University of Edinburgh. 2017 - 2018: Full time PhD, University of Edinburgh. 2016 – 2017: Research Fellow/ Part time PhD, Roslin Institute, University of Edinburgh. 2008 – 2016: Senior Research Scientist/ Part time PhD, Roslin Institute, University of Edinburgh. 2002 – 2008: Research Technical Scientist, Neuropathogenesis Unit, Edinburgh. Research We aim to characterise changes in brain structure in old age and investigate relationships between brain ageing and cognitive decline using a unique and extremely well-characterised model of healthy ageing (LBC 1936 cohort). Our hypothesis is that synaptic resilience in the form of robust synaptic numbers, structure and molecular composition underpins successful or healthy cognitive ageing. Recent publications Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype 2019. R Hesse; Maica Llavero Hurtado; Rosemary J. Jackson; Samantha L. Eaton; Abigail G Herrmann; Marti Colom-Cadena; Declan King; Jamie Rose; Jane Tulloch; Chris-Anne McKenzie; Colin Smith; Christopher Henstridge; Douglas Lamont; T M Wishart; T L Spires-Jones, DPhil Acta Neuropathologica Communications. Image This article was published on 2022-10-17
